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Huanglian Jiedu Decoction improves the"central-peripheral"inflammatory microenvironment and enhances the cognitive function of APP/PS1 mice by inhibiting the activation of NLRP3 inflammasome mediated by gut microbiota

Crossref DOI link: https://doi.org/10.1186/s13020-025-01180-4

Published Online: 2025-08-07

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhang, Yani

Wang, Jiahua

Li, Xuetao

Guo, Ruibo

Wang, Liyan

Liu, Yang

Yu, Yang

Kong, Liang
Funding

Funding for this research was provided by:

Liaoning Provincial Science and Technology Program Joint Plan (No. 2024-MSLH-289)

the Wu Jieping Medical Foundation Special Research Fund (No. 320.6750.2024-18-60)

the Open fund of Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine (No. zyzx2301)

National Natural Science Foundation of China (82404867)

Basic Research Project of Education Department of Liaoning Province (No. JYTQN2023471)
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Text and Data Mining valid from 2025-08-07

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Article History

Received: 21 May 2025

Accepted: 31 July 2025

First Online: 7 August 2025

Declarations

:

: The animal experiments were approved by the Ethics Committee of Liaoning University of Traditional Chinese Medicine (210000420240205).

: The authors declare no competing interests.

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