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Article History

Received: 2 March 2018

Accepted: 25 September 2018

First Online: 12 October 2018

Ethics approval and consent to participate

: The PharMetrics Plus™ database is fully compliant with the Health Insurance Portability and Accountability Act of 1996 (HIPAA) privacy regulations. As all patient-level data are HIPAA-compliant and certified anonymous, Institutional Review Board approval and patient informed consent were not required for this study. The databases were de-identified and complied with the Health Insurance Portability and Accountability Act of 1996 to preserve patient anonymity and confidentiality.

: NA

: MA Riedl has received fees from CSL Behring, Shire, BioCryst, Ionis, and Pharming for research support; he has served as consultant for CSL Behring, Shire, Adverum, Alnylam, BioCryst, KalVista, and Pharming; he has served on a speaker’s bureau for CSL Behring, Shire he Pharming. ME Manning has received research grants, speaking fees, and has served as a consultant for CSL Behring and Shire; he has received grants from BioCryst; he has served as a consultant and on a speaker’s bureau for Pharming; he has received grants and served on the speaker’s bureau for Dyax. E Burrell was an employee of CSL Behring at the time the study was conducted. N Joshi, D Patel, and M-H Tai are, or were at the time of the study, employees of Pharmerit which received funding from CSL Behring to conduct the research. A Banerji has received research grants from Shire and serves on the advisory board for Alnylam, Shire, CSL Behring, Pharming, and BioCryst. T Machnig and DJ Watson are or were employees and stockholders at CSL Behring during the study's conduct.

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