Updates are available Correction dated 2021-02-22

Article History

Received: 25 March 2020

Accepted: 9 August 2020

First Online: 26 August 2020

Change Date: 23 February 2021

Change Type: Correction

Change Details: A Correction to this paper has been published:

Change Details: https://doi.org/10.1186/s13023-021-01714-7

Ethics approval and consent to participate

: The ethics committee of the Rhineland-Palatinate Chamber of Physicians approved study conduct (reference number 837.504.16 (10822)).

: Consent to participate in the study was obtained from all participating patients. This included consent to the publication of results at an aggregated level.

: HG is employed by IGES Institut GmbH. CO and SK were employed by IGES Institut GmbH at the time the study was prepared. IGES Institut GmbH received funding from Shire Deutschland GmbH for the execution of the study and manuscript preparation