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Article History

Received: 17 December 2020

Accepted: 31 March 2021

First Online: 7 April 2021

Declarations

:

: The study protocol was approved by the Ethics Committee of the University of Messina (coordinating centre), and by the Local Ethics Committee of each participating centre. The study was performed in accordance to the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All persons gave their informed consent prior to their inclusion in the study.

: Not applicable.

: LO acknowledges speaker and consulting honoraria from Alnylam, Akcea and Pfizer; AM discloses having been on the advisory board for Alnylam, Akcea, and Pfizer; MR acknowledges speaker fee and consulting honoraria from Pfizer, and travel grant from Alnylam and Akcea; FC discloses being is in the Advisory Board of Pfizer and AKCEA; SF received speaking honoraria from Alnylam, Akcea, Pfizer, and travel grants from Alnylam and Akcea; ML received financial grants (honoraria and speaking) from Ackea, Alnylam, and Pfizer,and travel grants from Ackea, Alnylam, Pfizer, Kedrion, Csl Behring, and Grifols; MT reports a training grant from Pfizer and travel grant from Alnylam; LL received board grants from Akcea therapeutics; LGP received financial grants (honoraria and speaking) from Akcea and Alnylam, and travel grants from Akcea, Alnylam, and Pfizer; GC received a grant as temporary researcher in the GUP15010 study; AM received financial grants (honoraria and speaking) from Akcea and Alnylam; FM received speaker and consulting honoraria from Alnylam and Akcea; GA received advisory board honoraria and travel grant from Alnylam and Akcea; MG acknowledges donations from Sanofi Genzyme to support research activities, financial support from Pfizer, Alnylam and Sanofi Genzyme for participation in National and International Meetings; participation in Advisory Board of Pfizer; speaker honorarium from Sanofi Genzyme; GMF discloses having been on Advisory Boards for Alnylam and Akcea; he acknowledges speaker fee from Akcea and travel grant from Pfizer and Akcea; MS received financial grants (honoraria and speaking) from Ackea and Alnylam and travel grants from Grifols; DP served in advisory board for Alnylam and Akcea, received speaker honorarium from Alnylam and travel grants from Alnylam and Pfizer; FP acknowledges speaker fee and consulting honoraria from Alnylam, Akcea and Pfizer; FP Advisory Board Pfizer and AKCEA; GV acknowledges speaker fee and consulting honoraria from Alnylam, Akcea and Pfizer; LM, CS, GM, ST declare that they have no competing interests.