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Article History

Received: 19 March 2021

Accepted: 18 July 2021

First Online: 3 October 2021

Declarations

:

: Not applicable.

: Not applicable.

: DA acknowledges consultancy fees and institutional grants from Alnylam Pharmaceuticals and Pfizer Inc., and symposium honoraria from Pfizer Inc. outside the submitted work. VA reports consultancy fees from Pfizer Inc. and consultancy fees and institutional grants from Alnylam Pharmaceuticals outside the submitted work. JN-N’s institution received funding for clinical trials for Pfizer Inc., Akcea Therapeutics, and Eidos, and educational grants from Pfizer Inc., and received consulting income from Pfizer Inc., Eidos, Akcea Therapeutics, and Alnylam Pharmaceuticals outside the submitted work. MP reports consultancy and principal investigator fees from Alnylam Pharmaceuticals in relation to this work and from Alnylam Pharmaceuticals, Ionis Pharmaceuticals, and Pfizer Inc. outside the submitted work. NS reports funding for clinical trials for Pfizer, Akcea/Ionis, Alnylam, and Eidos, and consulting income from Pfizer, Akcea, and Alnylam. MSS acknowledges personal consultancy fees and symposium honoraria from Alnylam Pharmaceuticals and Pfizer Inc. outside the submitted work. The authors were not paid for their work developing the manuscript. The sponsor initially contacted the authors to ascertain their interest in writing the manuscript but had no role in the design, execution, interpretation, or writing of the study.