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Article History

Received: 10 March 2025

Accepted: 17 May 2025

First Online: 7 June 2025

Declarations

:

: The protocol had been reviewed and approved by the ethical committee from the coordinating center (Hospital Clínic Barcelona, CEIM HCB/2021/1099) and approved afterwards by all Ethical committees in the participating centers throughout the country.

: All patients included in the Registry consented to the use of their clinical data for investigational purposes.

: All the authors have read and agreed to the published version of the manuscript. All authors of the manuscript have read and agreed to its content and are accountable for all aspects of the accuracy and integrity of the manuscript in accordance with ICMJE criteria. The article is original, has not already been published in a journal, and is not currently under consideration by another journal. We agree to the terms of the BioMed Central Copyright and License Agreement.

: ZM: speaker fees from Orphalan and Gilead, consultancy fees from Orphalan, Alexion, Deep Genomics and Prime Medicine. Grants from Gilead. AM: speaker and consultant fees from Orphalan. MB: speaker fees from Abbvie, Advanz, Astellas, Chiesi, Gilead, Orphalan, consultancy fees from Advanz, Alexion, Chiesi, Deep Genomics, Grifols, and Orphalan; Grants from Gilead. The remaining authors do not disclaim conflicts of interest.