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Novel compound heterozygous mutations in plasminogen (p.Gly568Arg/p.Ala620Thr) impair protein structure and function in type II deficiency: mechanistic insights into a hereditary thrombogenic disorder

Crossref DOI link: https://doi.org/10.1186/s13023-025-04122-3

Published Online: 2025-12-15

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Lu, Yifan

Wang, Fengjiao

Yu, Dandan

Xie, Haixiao

Jin, Yanhui

Wang, Mingshan

Yang, Lihong https://orcid.org/0000-0002-9210-1022
Funding

Funding for this research was provided by:

the Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province (2022E10022)

the Zhejiang Provincial Medical and Health Science and Technology Plan (2024KY1268)
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Article History

Received: 26 June 2025

Accepted: 26 October 2025

First Online: 15 December 2025

Declarations

:

: The study was approved by the Ethics Committee of the First Affiliated Hospital of Wenzhou Medical University (KY2022-R193).

: Not applicable.

: The authors declare that they have no competing interests.

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