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Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

Crossref DOI link: https://doi.org/10.1186/s13024-018-0244-x

Published Online: 2018-03-01

Published Print: 2018-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Sosna, Justyna

Philipp, Stephan

Albay, Ricardo III

Reyes-Ruiz, Jorge Mauricio

Baglietto-Vargas, David

LaFerla, Frank M.

Glabe, Charles G.
Funding

Funding for this research was provided by:

National Institute on Aging (AG00538, AG00538, AG056507, AG027544)

Alzheimer's Association (NIRG-15-363477)

Cure Alzheimer's Fund
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Article History

Received: 21 December 2017

Accepted: 22 February 2018

First Online: 1 March 2018

Ethics approval and consent to participate

: All mouse experiments were performed according to animal protocols approved by the Institutional Animal Care and Use Committee at the University of California, Irvine.

: The authors have no conflict of interest.

: The authors declare that they have no competing interests.

: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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