Chen, Jason A.
Chen, Zhongbo
Won, Hyejung
Huang, Alden Y.
Lowe, Jennifer K.
Wojta, Kevin
Yokoyama, Jennifer S.
Bensimon, Gilbert
Leigh, P. Nigel
Payan, Christine
Shatunov, Aleksey
Jones, Ashley R.
Lewis, Cathryn M.
Deloukas, Panagiotis
Amouyel, Philippe
Tzourio, Christophe
Dartigues, Jean-Francois
Ludolph, Albert
Boxer, Adam L.
Bronstein, Jeff M.
Al-Chalabi, Ammar
Geschwind, Daniel H.
Coppola, Giovanni http://orcid.org/0000-0003-2105-1061
Funding for this research was provided by:
National Institute of Neurological Disorders and Stroke (F31 NS084556)
Article History
Received: 16 May 2018
Accepted: 29 June 2018
First Online: 8 August 2018
Ethics approval and consent to participate
: Written informed consent was obtained for all patients participating in the Allon Therapeutics davunetide trial and the NNIPPS trial, and IRB approval was obtained from the corresponding Institutional Review Boards. For the NNIPPS study, The protocol and amendments were reviewed and approved by the Comité de Protection des Personnes of Pitié-Salpêtrière Hospital (France), the UK Multicentre Research Ethics Committee (MREC) (UK), Ethikkommission of the University of Ulm (Germany) and by local Institutional Review Boards (Ethics Committees) where appropriate (UK, Germany). For the BBBIPPS study, the protocol and amendments were reviewed and approved by the Comité de Protection des Personnes of Pitié-Salpêtrière Hospital (France). Additional data was obtained via NIAGADS and dbGAP in accordance with data access policies. The Institutional Review Board at the University of California, Los Angeles, approved the joint study design, including review of outside consent forms.
: Not applicable.
: J.A.C. is founder of Verge Genomics, a biotechnology company, and holds an equity stake. P.A. is a member of the Scientific Advisory Board of Genoscreen, a biotechnology company, and Director of the Fondation Plan Alzheimer, a non-profit organization. J-F.G. has received research grant funding from Roche.
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