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The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

Crossref DOI link: https://doi.org/10.1186/s13024-018-0280-6

Published Online: 2018-09-06

Published Print: 2018-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Xiang, Xianyuan

Piers, Thomas M.

Wefers, Benedikt

Zhu, Kaichuan

Mallach, Anna

Brunner, Bettina

Kleinberger, Gernot

Song, Wilbur

Colonna, Marco

Herms, Jochen

Wurst, Wolfgang

Pocock, Jennifer M.

Haass, Christian
Funding

Funding for this research was provided by:

Deutsche Forschungsgemeinschaft (EXC 1010 SyNergy)

Koselleck Project (HA1737/16-1)

German Federal Ministry of Education and Research (01EK1605C)

Biotechnology and Biological Sciences Research Council (BB/M009513/1)

Innovative Medicines Initiative 2 Joint Undertaking (No 115976)

National Institute on Aging (RF1 AG051485)
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Article History

Received: 8 August 2018

Accepted: 21 August 2018

First Online: 6 September 2018

Ethics approval

: All mice were handled according to institutional guidelines approved by the animal welfare and use committee of the government of Upper Bavaria. Ethics committee from Ludwig-Maximilians- University and University College London approved this research project using human tissue.

: Consent for publication on using human tissue in this study is detailed in the Material Transfer Agreement (MTA) between organizations.

: C.H. collaborates with DENALI Therapeutics and received a speaker honorarium from Novartis and Roche. The other authors declare that they have no competing interests.

: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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