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Authors
Martiskainen, Henna
Willman, Roosa-Maria
Harju, Päivi
Heikkinen, Sami
Heiskanen, Mette
Müller, Stephan A.
Sinisalo, Rosa
Takalo, Mari
Mäkinen, Petra
Kuulasmaa, Teemu
Pekkala, Viivi
Galván del Rey, Ana
Juopperi, Sini-Pauliina
Jeskanen, Heli
Kervinen, Inka
Saastamoinen, Kirsi
,
Palotie, Aarno
Daly, Mark
Riley-Gills, Bridget
Jacob, Howard
Viollet, Coralie
Petrovski, Slavé
Chen, Chia-Yen
John, Sally
Okafo, George
Plenge, Robert
Maranville, Joseph
McCarthy, Mark
Pendergrass, Rion
Davitte, Jonathan
Auro, Kirsi
Longerich, Simonne
Mälarstig, Anders
Vlahiotis, Anna
Klinger, Katherine
Chatelain, Clement
Gossel, Matthias
Estrada, Karol
Graham, Robert
Waterworth, Dawn
O´Donnell, Chris
Renaud, Nicole
Mäkelä, Tomi P.
Kaprio, Jaakko
Ruddock, Minna
Virolainen, Petri
Hakanen, Antti
Kilpi, Terhi
Perola, Markus
Partanen, Jukka
Raivio, Taneli
Tikkanen, Jani
Serpi, Raisa
Kristiansson, Kati
Kosma, Veli-Matti
Laukkanen, Jari
Hautalahti, Marco
Tuovila, Outi
Waring, Jeffrey
Riley-Gillis, Bridget
Rahimov, Fedik
Tachmazidou, Ioanna
Ding, Zhihao
Jung, Marc
Tuoken, Hanati
Biswas, Shameek
Raghavan, Neha
Huertas-Vazquez, Adriana
Sul, Jae-Hoon
Hu, Xinli
Hedman, Åsa
Obeidat, Ma´en
Chung, Jonathan
Zierer, Jonas
Niemi, Mari
Ripatti, Samuli
Schleutker, Johanna
Arvas, Mikko
Carpén, Olli
Hinttala, Reetta
Kettunen, Johannes
Mannermaa, Arto
Aalto-Setälä, Katriina
Kähönen, Mika
Mäkelä, Johanna
Kälviäinen, Reetta
Julkunen, Valtteri
Remes, Anne
Peltola, Jukka
Raivio, Minna
Tienari, Pentti
Kallionpää, Roosa
Partanen, Juulia
Ziemann, Adam
Smaoui, Nizar
Lehtonen, Anne
Eaton, Susan
Runz, Heiko
Lahdenperä, Sanni
Bowers, Natalie
Teng, Edmond
Xu, Fanli
Addis, Laura
Eicher, John
Li, Qingqin S.
He, Karen
Khramtsova, Ekaterina
Färkkilä, Martti
Koskela, Jukka
Pikkarainen, Sampsa
Jussila, Airi
Kaukinen, Katri
Blomster, Timo
Kiviniemi, Mikko
Voutilainen, Markku
Lu, Tim
McCarthy, Linda
Hart, Amy
Guan, Meijian
Miller, Jason
Kalpala, Kirsi
Miller, Melissa
Eklund, Kari
Palomäki, Antti
Isomäki, Pia
Pirilä, Laura
Kaipiainen-Seppänen, Oili
Huhtakangas, Johanna
Mars, Nina
Lertratanakul, Apinya
Hochfeld, Marla
Gordillo, Jorge Esparza
Farias, Fabiana
Bing, Nan
Laitinen, Tarja
Pelkonen, Margit
Kauppi, Paula
Kankaanranta, Hannu
Harju, Terttu
Lahesmaa, Riitta
Chen, Hubert
Betts, Joanna
Mishra, Rajashree
Mouded, Majd
Ngo, Debby
Niiranen, Teemu
Vaura, Felix
Salomaa, Veikko
Metsärinne, Kaj
Aittokallio, Jenni
Hernesniemi, Jussi
Gordin, Daniel
Sinisalo, Juha
Taskinen, Marja-Riitta
Tuomi, Tiinamaija
Hiltunen, Timo
Elliott, Amanda
Reeve, Mary Pat
Ruotsalainen, Sanni
Paul, Dirk
Chu, Audrey
Reilly, Dermot
Mendelson, Mike
Parkkinen, Jaakko
Meretoja, Tuomo
Joensuu, Heikki
Mattson, Johanna
Salminen, Eveliina
Auranen, Annika
Karihtala, Peeter
Auvinen, Päivi
Elenius, Klaus
Pitkänen, Esa
Popovic, Relja
Fabre, Margarete
Schutzman, Jennifer
Kulkarni, Diptee
Porello, Alessandro
Loboda, Andrey
Lehtonen, Heli
McDonough, Stefan
Vuoti, Sauli
Kaarniranta, Kai
Turunen, Joni A.
Ollila, Terhi
Uusitalo, Hannu
Karjalainen, Juha
Liu, Mengzhen
Loomis, Stephanie
Strauss, Erich
Chen, Hao
Tasanen, Kaisa
Huilaja, Laura
Hannula-Jouppi, Katariina
Salmi, Teea
Peltonen, Sirkku
Koulu, Leena
Choy, David
Wu, Ying
Pussinen, Pirkko
Salminen, Aino
Salo, Tuula
Rice, David
Nieminen, Pekka
Palotie, Ulla
Siponen, Maria
Suominen, Liisa
Mäntylä, Päivi
Gursoy, Ulvi
Anttonen, Vuokko
Sipilä, Kirsi
Pendergrass, Rion
Laivuori, Hannele
Kurra, Venla
Kotaniemi-Talonen, Laura
Heikinheimo, Oskari
Kalliala, Ilkka
Aaltonen, Lauri
Jokimaa, Varpu
Vääräsmäki, Marja
Uimari, Outi
Morin-Papunen, Laure
Niinimäki, Maarit
Piltonen, Terhi
Kivinen, Katja
Widen, Elisabeth
Tukiainen, Taru
Välimäki, Niko
Laakkonen, Eija
Tyrmi, Jaakko
Silven, Heidi
Sliz, Eeva
Arffman, Riikka
Savukoski, Susanna
Laisk, Triin
Pujol, Natalia
Kumar, Janet
Hovatta, Iiris
Isometsä, Erkki
Ollila, Hanna
Suvisaari, Jaana
Mäkitie, Antti
Bizaki-Vallaskangas, Argyro
Toppila-Salmi, Sanna
Willberg, Tytti
Saarentaus, Elmo
Aarnisalo, Antti
Rahikkala, Elisa
Aittomäki, Kristiina
Åberg, Fredrik
Kurki, Mitja
Havulinna, Aki
Mehtonen, Juha
Palta, Priit
Hassan, Shabbeer
Parolo, Pietro Della Briotta
Zhou, Wei
Maasha, Mutaamba
Lemmelä, Susanna
Rivas, Manuel
Liu, Aoxing
Lehisto, Arto
Ganna, Andrea
Llorens, Vincent
Heyne, Henrike
Rämö, Joel
Rodosthenous, Rodos
Strausz, Satu
Palotie, Tuula
Palin, Kimmo
Garcia-Tabuenca, Javier
Siirtola, Harri
Kiiskinen, Tuomo
Lee, Jiwoo
Tsuo, Kristin
Hyvärinen, Kati
Ritari, Jarmo
Pylkäs, Katri
Karjalainen, Minna
Mantere, Tuomo
Kangasniemi, Eeva
Pitkänen, Nina
Lessard, Samuel
Chatelain, Clément
Kallio, Lila
Wahlfors, Tiina
Punkka, Eero
Siltanen, Sanna
Kuopio, Teijo
Jalanko, Anu
Shen, Huei-Yi
Kajanne, Risto
Aavikko, Mervi
Cooper, Helen
Öller, Denise
Leinonen, Rasko
Palin, Henna
Linna, Malla-Maria
Kanai, Masahiro
Zheng, Zhili
Lahtela, L. Elisa
Kaunisto, Mari
Kilpeläinen, Elina
Sipilä, Timo P.
Dada, Oluwaseun Alexander
Ghazal, Awaisa
Kytölä, Anastasia
Weldatsadik, Rigbe
Donner, Kati
Loukola, Anu
Laiho, Päivi
Sistonen, Tuuli
Kaiharju, Essi
Laukkanen, Markku
Järvensivu, Elina
Lähteenmäki, Sini
Männikkö, Lotta
Wong, Regis
Toivola, Auli
Brunfeldt, Minna
Mattsson, Hannele
Koskelainen, Sami
Hiekkalinna, Tero
Paajanen, Teemu
Luo, Shuang
Padmanabhuni, Shanmukha Sampath
Niemi, Marianna
Gracia-Tabuenca, Javier
Helminen, Mika
Luukkaala, Tiina
Vähätalo, Iida
Tammerluoto, Jyrki
Smith, Sarah
Southerington, Tom
Lehto, Petri
Niiranen, Marja
Heikkinen, Sami V.
Kurki, Mitja I.
Marttila, Jarkko
Mäkinen, Petri I.
Rostalski, Hannah
Hietanen, Tomi
Ngandu, Tiia
Lehtisalo, Jenni
Bellenguez, Céline
Lambert, Jean-Charles
Haass, Christian
Rinne, Juha
Hakumäki, Juhana
Rauramaa, Tuomas
Krüger, Johanna
Soininen, Hilkka
Haapasalo, Annakaisa
Lichtenthaler, Stefan F.
Leinonen, Ville
Solje, Eino
Hiltunen, Mikko https://orcid.org/0000-0003-1508-4908
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Funding
Funding for this research was provided by:
Academy of Finland (355604, 338182, 330178, 339767)
Faculty of Health Sciences, University of Eastern Finland
Sigrid Juséliuksen Säätiö
The Strategic Neuroscience Funding of the University of Eastern Finland
Alzheimer's Association (ADSF-24-1284326-C)
The State Research Funding KUH-VTR
Doctoral Programme in Molecular Medicine
Deutsche Forschungsgemeinschaft (390857198, 390857198, HA1737/16-1)
EU Joint Programme – Neurodegenerative Disease Research (334802, 01ED2002B, 01ED2002B)
European Regional Development Fund
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Article History
Received: 16 May 2024
Accepted: 20 March 2025
First Online: 29 April 2025
Declarations
:
: All study protocols concerning human samples were approved by the Medical Research Ethics Committee of Wellbeing Services County of North Savo (formerly Medical Research Ethics Committee of North Savo Hospital District). Access to biobank samples and participant recontacting were approved by the Scientific Steering Committees of Biobank of Eastern Finland (BB_2020 - 0062, BB23 - 0270) and Auria Biobank (BB_2020 - 0062). Written informed consent was obtained from all participants.The FinnGen study is approved by Finnish Institute for Health and Welfare (permit numbers: THL/2031/6.02.00/2017, THL/1101/5.05.00/2017, THL/341/6.02.00/2018, THL/2222/6.02.00/2018, THL/283/6.02.00/2019, THL/1721/5.05.00/2019 and THL/1524/5.05.00/2020), Digital and population data service agency (permit numbers: VRK43431/2017–3, VRK/6909/2018–3, VRK/4415/2019–3), the Social Insurance Institution (permit numbers: KELA 58/522/2017, KELA 131/522/2018, KELA 70/522/2019, KELA 98/522/2019, KELA 134/522/2019, KELA 138/522/2019, KELA 2/522/2020, KELA 16/522/2020), Findata (permit numbers THL/2364/14.02/2020, THL/4055/14.06.00/2020, THL/3433/14.06.00/2020, THL/4432/14.06/2020, THL/5189/14.06/2020, THL/5894/14.06.00/2020, THL/6619/14.06.00/2020, THL/209/14.06.00/2021, THL/688/14.06.00/2021, THL/1284/14.06.00/2021, THL/1965/14.06.00/2021, THL/5546/14.02.00/2020, THL/2658/14.06.00/2021, THL/4235/14.06.00/2021), Statistics Finland (permit numbers: TK- 53–1041 - 17 and TK/143/07.03.00/2020 (earlier TK- 53–90 - 20) TK/1735/07.03.00/2021, TK/3112/07.03.00/2021) and Finnish Registry for Kidney Diseases (permission/extract from the meeting minutes on 4 th July 2019).The Biobank Access Decisions for FinnGen samples and data utilized in FinnGen Data Freeze 12 include: THL Biobank BB2017_55, BB2017_111, BB2018_19, BB_2018_34, BB_2018_67, BB2018_71, BB2019_7, BB2019_8, BB2019_26, BB2020_1, BB2021_65, Finnish Red Cross Blood Service Biobank 7.12.2017, Helsinki Biobank HUS/359/2017, HUS/248/2020, HUS/430/2021 §28, §29, HUS/150/2022 §12, §13, §14, §15, §16, §17, §18, §23, §58, §59, HUS/128/2023 §18, Auria Biobank AB17 - 5154 and amendment #1 (August 17 2020), Biobank Borealis of Northern Finland_2017_1013, 2021_5010, 2021_5010 Amendment, 2021_5018, 2021_5018 Amendment, 2021_5015, 2021_5015 Amendment, 2021_5015 Amendment_2, 2021_5023, 2021_5023 Amendment, 2021_5023 Amendment_2, 2021_5017, 2021_5017 Amendment, 2022_6001, 2022_6001 Amendment, 2022_6006 Amendment, 2022_6006 Amendment, 2022_6006 Amendment_2, BB22 - 0067, 2022_0262, 2022_0262 Amendment, Biobank of Eastern Finland 1186/2018 and amendment 22§/2020, 53§/2021, 13§/2022, 14§/2022, 15§/2022, 27§/2022, 28§/2022, 29§/2022, 33§/2022, 35§/2022, 36§/2022, 37§/2022, 39§/2022, 7§/2023, 32§/2023, 33§/2023, 34§/2023, 35§/2023, 36§/2023, 37§/2023, 38§/2023, 39§/2023, 40§/2023, 41§/2023, Finnish Clinical Biobank Tampere MH0004 and amendments (21.02.2020 & 06.10.2020), BB2021 - 0140 8§/2021, 9§/2021, §9/2022, §10/2022, §12/2022, 13§/2022, §20/2022, §21/2022, §22/2022, §23/2022, 28§/2022, 29§/2022, 30§/2022, 31§/2022, 32§/2022, 38§/2022, 40§/2022, 42§/2022, 1§/2023, Central Finland Biobank 1–2017, BB_2021 - 0161, BB_2021 - 0169, BB_2021 - 0179, BB_2021 - 0170, BB_2022 - 0256, BB_2022 - 0262, BB22 - 0067, Decision allowing to continue data processing until 31 st Aug 2024 for projects: BB_2021 - 0179, BB22 - 0067,BB_2022 - 0262, BB_2021 - 0170, BB_2021 - 0164, BB_2021 - 0161, and BB_2021 - 0169, and Terveystalo Biobank STB 2018001 and amendment 25 th Aug 2020, Finnish Hematological Registry and Clinical Biobank decision 18 th June 2021, Arctic biobank P0844: ARC_2021_1001.
: Consent for publication was obtained from participants whose individual data is presented in the manuscript.
: CH collaborates with Denali Therapeutics and is a member of the advisory boards of AviadoBio and Cure Ventures. The other authors declare that they have no competing interests.
