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Authors
Holmes, Brandon B. https://orcid.org/0000-0002-1153-840X
Weigel, Thaddeus K.
Chung, Jesseca M.
Kaufman, Sarah K.
Apresa, Brandon I.
Byrnes, James R.
Kumru, Kaan S.
Vaquer-Alicea, Jaime
Gupta, Ankit
Rose, Indigo V. L.
Zhang, Yun
Nana, Alissa L.
Alter, Dina
Grinberg, Lea T.
Spina, Salvatore
Leung, Kevin K.
Miller, Bruce L.
Condello, Carlo
Kampmann, Martin
Seeley, William W.
Coutinho-Budd, Jaeda C.
Wells, James A.
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Funding
Funding for this research was provided by:
BrightFocus Foundation (BrightFocus Foundation)
Shenandoah Community Foundation (Shenandoah Community Foundation)
Brain Institute, University of Virginia (Brain Institute, University of Virginia)
National Institute of Neurological Disorders and Stroke (1K08NS133290, R01NS121101)
National Institute of General Medical Sciences (R35GM122451)
National Institutes of Health (RF1AG061874, K24AG053435, P01AG019724, P30AG062422, U19AG063911, U01AG057195)
Alzheimer's Association (ZEN-22-969903)
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Article History
Received: 21 February 2025
Accepted: 25 July 2025
First Online: 29 August 2025
Declarations
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: All animal procedures were conducted in accordance with the guidelines set forth by the Institutional Animal Care and Use Committee at the University of Virginia School of Medicine, and study protocols were reviewed and approved prior to performing the experimental procedures described.
: All authors have approved the contents of this manuscript and provided consent for publication.
: B.B.H has the following US patents: Therapeutic Anti-Tau Antibodies (US9834596), Method for Detection of Aggregates in Biological Samples (US9910048) and Methods and Compositions Related to Heparinoids (WO2021142312A1). M.K. is a co-scientific founder of Montara Therapeutics and serves on the Scientific Advisory Boards of Engine Biosciences, Casma Therapeutics, Alector, and Montara Therapeutics, and is an advisor to Modulo Bio and Recursion Therapeutics.
