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Authors
Castanho, Isabel https://orcid.org/0000-0003-1413-626X
Naderi Yeganeh, Pourya https://orcid.org/0000-0002-4693-8331
Boix, Carles A. https://orcid.org/0000-0001-9212-856X
Morgan, Sarah L.
Mathys, Hansruedi
Prokopenko, Dmitry
White, Bartholomew
Soto, Larisa M.
Pegoraro, Giulia
Shah, Saloni
Ploumakis, Athanasios
Kalavros, Nikolas
Bennett, David A.
Lange, Christoph
Kim, Doo Yeon
Bertram, Lars
Tsai, Li-Huei
Kellis, Manolis
Tanzi, Rudolph E.
Hide, Winston https://orcid.org/0000-0002-8621-3271
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Funding
Funding for this research was provided by:
National Institute on Aging (R01AG082093, R01AG062547, U19AG073172, P30AG10161, P30AG72975, R01AG15819, R01AG17917, U01AG46152, U01AG61356, R01AG048080, R01AG014713, RF1AG062377, RF1AG054321, R01AG054012, R01AG081017, R01AG062335, R01AG074003, U01NS110453, R01AG058002)
Alzheimer's Association (AARF-23-1148927)
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Article History
Received: 11 February 2025
Accepted: 28 August 2025
First Online: 1 October 2025
Declarations
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: Detailed information regarding ethical approval and consent for the bulk RNAseq data [, ], snRNAseq data [, ], and whole-genome data [] has previously been described. ROSMAP studies were approved by the Institutional Review Board of Rush University Medical Center. Whole genome sequencing studies were approved by the Institutional Review Board from Massachusetts General Hospital (protocols 2015P000111 and 2019P001879).Human brain tissue used for immunostaining experiments, collected at Beth Israel Deaconess Medical Center (BIDMC), was approved by the BIDMC Institutional Review Board (IRB Protocol 2023P000848).
: Not applicable.
: Authors declare that they have no competing interests.
