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Article History

Received: 30 January 2026

Accepted: 1 April 2026

First Online: 16 April 2026

Declarations

:

: Not applicable.

: This manuscript relied on the use of Large Language Models (Chat GPT, 2026) for preparation of the tables, the appendix, glossary and editing of the manuscript. The author declares to retain the ultimate responsibility for the accuracy, integrity, and originality of the content of this manuscript, in compliance the 2026 RULE-AP consensus paper [ ].

: Dr. Lynn owns Lyntek Medical Technologies, a research and development company in Columbus, Ohio, USA, which designs software for analysis of electronic medical records data designed for protocol failure mode detection.