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Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis

Crossref DOI link: https://doi.org/10.1186/s13045-018-0689-y

Published Online: 2019-01-08

Published Print: 2019-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Raimondo, Stefania

Saieva, Laura

Vicario, Emanuela

Pucci, Marzia

Toscani, Denise

Manno, Mauro

Raccosta, Samuele

Giuliani, Nicola

Alessandro, Riccardo https://orcid.org/0000-0002-9935-1040
Funding

Funding for this research was provided by:

Associazione Italiana per la Ricerca sul Cancro (18783, 20299)

Fondazione Italiana per la Ricerca sul Cancro (17927)
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Article History

Received: 3 October 2018

Accepted: 25 December 2018

First Online: 8 January 2019

Ethics approval and consent to participate

: This study was conducted in full conformance with the principles of the Declaration of Helsinki. All patients provided written informed consent. The Institutional Review Board of the University of Parma (Italy) approved this part of the study.

: Not applicable.

: The authors declare that they have no competing interest exists.

: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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