Document is current

Article History

Received: 28 August 2019

Accepted: 9 December 2019

First Online: 30 December 2019

Ethics approval and consent to participate

: The study was approved by the MD Anderson Cancer Center Institutional Review Board. The trial was registered at (NCT00851032).All patients provided written informed consent stating that they were aware of the experimental nature of the specific phase I study in which they participated. Clinical trials and analyses were conducted with the approval of and in accordance with the guidelines of the MD Anderson Cancer Center Institutional Review Board.

: Not applicable

: Apostolia-Maria Tsimberidou—Research Funding: IMMATICS, Parker Institute for Cancer Immunotherapy, Tempus, EMD Serono; Baxalta; Foundation Medicine; ONYX; Bayer; Boston Biomedical; Placon Therapeutics; Karus Therapeutics; Tvardi; OBI Pharma. Consulting or Advisory Role: Roche, Covance, Genentech.David S Hong—Research Funding: Adaptimmune, Abbvie, Amgen, AstraZeneca, Bayer, BMS, Daiichi-Sanko, Eisai, Genentech, Genmab, Ignyta, Infinity, Kite Kyowa, Lilly, LOXO, Mirati, Merck, Medimmune, Molecular Template, Novartis, Pfizer, Takeda. Travel, Accommodations, Expenses: LOXO, MiRNA. Consulting or Advisory Role: Baxter, Bayer, Guidepoint Global, Janssen, Genentech, Takeda. Other ownership interests: Molecular Match (Advisor), Oncoresponse (founder).Jennifer J Wheler—Current employee of TScan Therapeutics. Stock owner in TScan Therapeutics.Gerald S. Falchook—Research Funding: Millennium, EMD Serono, Celgene, MedImmune, Genmab, Vegenics, Novartis, AstraZeneca, Incyte, ARMO BioSciences, KollTan Pharmaceuticals, 3-V Biosciences, Abbvie, Aileron Therapeutics, DeMar Pharmaceuticals, eFFECTOR Therapeutics, Strategia Therapeutics, FujiFilm, Hutchison MediPharma, Regeneron, Biothera, Curegenix, Curis, Lilly, Jounce Therapeutics, OncoMed, Precision Oncology, Syndax, Taiho Pharmaceuticals, Tesaro, Takeda, BeiGene, Ignyta, Merck, Rgenix, Tarveda Therapeutics, Tocagen, Loxo. Royalties: Handbook of Targeted Cancer Therapy. Travel, Accommodations, Expenses: Millennium, Sarah Cannon Research Institute, EMD Serono, Bristol-Myers Squibb.Filip Janku—Research Funding: Novartis, FujiFilm Pharmaceuticals, Plexxikon, Deciphera Pharmaceuticals, Symphogen, Asana, BioMed Valley Discoveries, Bristol-Myers Squibb, Genentech, Astellas Pharma, Agios, Pl QUR Therapeutics AG, Bayer, and Proximagen. Consulting Role: Deciphera Pharmaceuticals, Novartis, Synlogic, IFM Therapeutics, lllumina, GRAIL. Valeant, Sotio, Pure Tech Health, Guardant Health Trovagene, and lmmunoMet. Ownership interest in Trovagene.Aung Naing—Research Funding: NCI; EMD Serono; MedImmune; Healios Onc. Nutrition; Atterocor; Amplimmune; ARMO BioSciences; Karyopharm Therapeutics; Incyte; Novartis; Regeneron; Merck; BMS; Pfizer; CytomX Therapeutics; Neon Therapeutics; Calithera Biosciences; TopAlliance Biosciences; Immune Deficiency Foundation (Spouse). Advisory board: CytomX Therapeutics and Novartis. Travel and accommodation expense from ARMO Biosciences.Siqing Fu—Research Funding: Anaeropharma Science, Inc.; Aprea AB; AstraZeneca; Eli Lilly and Company; Endocyte; Ignyta; Millennium; NCCI; Novartis; OncoMed Pharmaceuticals, Inc.; Vertex Pharmaceuticals; Hengrui. Travel and Accommodations: Hebei Medical University, EMD Serono.Sarina Piha-Paul—Research Funding: AbbVie, Inc.; Aminex Therapeutics; Bristol Myers Squibb; Curis, Inc.; Five Prime Therapeutics; GlaxoSmithKline; Helix BioPharma Corp.; Incyte, Inc.; MedImmune; Medivation, Inc.; Merck Sharp and Dohme; Novartis; Pieris; Pfizer; Principia Biopharma, Inc.; Puma Biotechnology, Inc.; Seattle Genetics; Taiho; Tesaro; TransThera Bio; XuanZhu Biopharma.Patrick Hwu—Advisory role: Immatics, Dragonfly, Sanofi, GlaxoSmithKline.Razelle Kurzrock—Research Funding: Incyte, Genentech, Merck Serono, Pfizer, Sequenom, Foundation Medicine, Guardant Health, Konica Minolta, Boehringer Ingelheim, and Debiopharm. Consultant fees: LOXO, X-Biotech, Actuate Therapeutics, Roche, Soluventis and NeoMed. Speaker fees: Roche. Ownership interest: CureMatch, Inc. Stock owner: IDbyDNA.The other authors declare that they have no competing interests.