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Article History

Received: 28 May 2021

Accepted: 30 July 2021

First Online: 18 August 2021

Declarations

:

: The protocol was approved by the FDA and the Institutional Review Board at The University of Texas MD Anderson Cancer Center. The study was conducted in accordance with the Declaration of Helsinki and the International Conference on Harmonization Good Clinical Practice guidelines. All the study participants provided written informed consent before enrollment.

: Patient consent for publication is not required. Patients consented to participate in the study.

: A-MT has received research funding from Merck KGaA, Darmstadt, Germany, Immatics, Parker Institute for Cancer Immunotherapy, Tempus, OBI Pharma, Baxalta, ONYX, Bayer, Boston Biomedical, Placon Therapeutics, Karus Therapeutics, and Tvardi Therapeutics, and has provided consulting or advisory services for Genentech, Tempus and Vincerx. GL has received research funding from Merck KgaA, Darmstadt, Germany, Merck, Sharp & Dohme, EMD Serono, Inc. (a business of Merck KGaA, Darmstadt, Germany), AstraZeneca, Blueprint Medicines, Tesaro, Bavarian Nordic, Novartis, G1 Therapeutics, Adaptimmune, Bristol-Myers Squibb, GSK, Abbvie, Rgenix, Pfizer, Roche, Genentech, Lilly, and Janssen, has received honoraria from Boehringer Ingelheim and Merck, Sharp & Dohme, has received reimbursement for travel and accommodation from Pfizer and ER Squibb Sons LLC, and has provided consultancy for Pfizer and AstraZeneca. RKu has received research funding from Genentech, Merck KGaA, Pfizer, Boehringer Ingelheim, TopAlliance, Takeda, Incyte, Debiopharm, Medimmune, Sequenom, Foundation Medicine, Konica Minolta, Grifols, Omniseq, and Guardant, has received consultancy and/or speaker and/or advisory board fees from X-Biotech, Neomed, Pfizer, Actuate Therapeutics, Roche, Turning Point Therapeutics, TD2/Volastra, Bicara Therapeutics, Inc., has an equity interest in IDbyDNA and CureMatch Inc., serves on the Board of CureMatch and CureMetrix, and is a co-founder of CureMatch. JS, HT and RKa are/were employees of EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany). HP has received research funding from Ambrx, Amgen, Aprea Therapeutics AB, Array BioPharma, Bayer, BeiGene, BJ Bioscience, Bristol-Myers Squibb, Daiichi Pharmaceutical, Eli Lilly, Elicio Therapeutics, EMD Serono, Inc. (a business of Merck KGaA, Darmstadt, Germany), Genentech, Gilead Sciences, GlaxoSmithKline, Gossamer Bio, Hoffman-LaRoche, Hutchison MediPharma, ImmuneOncia Therapeutics, Incyte, Jounce Therapeutics, Mabspace Biosciences, MacroGenics, Medimmune, Medivation, Merck KgaA, Darmstadt, Germany, Millennium, Mirati Therapeutics, Novartis Pharmaceuticals, Oncologie, Pfizer, PsiOxus Therapeutics, Puma Biotechnology, Regeneron Pharmaceuticals, Seattle Genetics, Synermore Biologics, Taiho Pharmaceutical, TopAlliance Biosciences, Turning Point Therapeutics, Vedanta Biosciences, Vertex Pharmaceuticals, and Xencor Inc. BE-L is an employee of Merck KGaA, Darmstadt, Germany. WX was an employee of Merck Serono SA, Lausanne, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany). DJ provides consultancy to Novartis, Genentech, Eisai, Syros, Relay Therapeutics, MapKure, and Vibliome, and has received research funding (to the institution) from EMD Serono, Billerica, MA, USA (a business of Merck KGaA, Darmstadt, Germany), Novartis, Genentech, Eisai, Syros, Pfizer, Infinity Pharmaceuticals, Takeda, InventisBio, Arvinas, Ribon Therapeutics and Acetylon Pharmaceuticals. JS has received research support from the Institute for Drug Development, Cancer Therapy and Research Center at University of Texas Health Science Center San Antonio Cancer Center. CV, AMW, JN and MM have nothing to disclose.