Updates are available Correction dated 2022-03-23

Article History

Received: 21 September 2021

Accepted: 18 December 2021

First Online: 6 January 2022

Change Date: 23 March 2022

Change Type: Correction

Change Details: A Correction to this paper has been published:

Change Details: https://doi.org/10.1186/s13045-022-01239-x

Declarations

:

: PACE was approved by local ethics committees and was conducted in accordance with the Declaration of Helsinki and the International Council for Harmonisation guidelines for good clinical practice. All patients provided written informed consent.

: All authors have critically reviewed the manuscript and consent to publication.

: J.L.J.: Consulting/advisory role (Takeda), research funding (Novartis); J.M.G.: Employment and stock/other ownership (family member: Vertex Pharmaceuticals), consulting/advisory role (Clinical Events Committee, ACI; AbbVie; Baim Institute; Parexel), research funding (ReCor Medical); S.E.K.: research funding (Bristol Myers Squibb, Genentech, Medtronic), consulting/advisory role (AbbVie, Abbott, AstraZeneca, BMS, Janssen, Takeda, Medtronic); V.M.: Consulting/advisory role (Takeda, Novartis, Amgen, Bayer), honoraria (Amgen, Novartis), research funding (Novartis, Rigel); M.C.P.: Endpoint adjudication committee (Takeda); J.S.: Employment, leadership role, stock/other ownership (WCG Clinical); M.M.: Consulting/advisory role, travel/accommodations/expenses, and honoraria (Novartis, BMS, Pfizer, Takeda), research funding (all to institution: Sun Pharma, Novartis, BMS); K.C.: Honoraria, consulting/advisory role, travel/accommodations/expenses (Takeda, Abbott, CSI, Philips, Abiomed, Cordis, Boston Scientific), research funding (Abbott, ARIAD, Takeda); E.B.: Honoraria, consulting/advisory role, travel/accommodations/expenses (ARIAD); MD: Consulting/advisory role (Blueprint, Fusion Pharma, Takeda, Humana, Ascentage Pharma, Adelphi, Medscape, Novartis), research funding (Takeda, Pfizer, Novartis, Incyte, SPARC, Blueprint, Leukemia & Lymphoma Society); A.H.: Research funding (Incyte, BMS, Novartis, Pfizer); J.P.I.: Consulting/advisory role (AbbVie, Janssen, AstraZeneca, Novartis, TG Therapeutics, Takeda), speakers bureau (AbbVie, Janssen, AstraZeneca, Takeda), research funding (MEI, Sunesis), patents/royalties/other intellectual property (Sellas); F.N.: Honoraria, speakers bureau, travel/accommodations/expenses (Novartis, Incyte Biosciences), consulting/advisory role (Sun Pharma), research funding (Incyte Biosciences); D.W.K.: Research funding (Novartis, BMS, Pfizer, Takeda, Sun Pharma, Il-Yang Pharm. Co., Ltd.), advisory board (Novartis, BMS); D.J.D.: Consulting/advisory role (Incyte, Pfizer, BMS, Amgen, Novartis, Celgene, Immunogen, Takeda, Blueprint Medicines), research funding (all to institution: Novartis, AbbVie, GlycoMimetics, Blueprint Medicines); H.K.: Honoraria (AbbVie, Amgen, ARIAD, BMS, Immunogen, Orsenix, Pfizer, Agios, Takeda, Actinium Pharmaceuticals), research funding (all to institution: Pfizer, Amgen, BMS, Novartis, ARIAD, Astex Pharmaceuticals, AbbVie, Agios, Cyclacel, Immunogen, Jazz Pharmaceuticals); J.X.: Employment (Takeda); T.H.: Employment (Takeda); S.S.: Employment (Takeda); D.N.: Employment (Takeda); J.C.: Consulting/advisory role (BMS, Novartis, Pfizer, Takeda), research funding (Novartis, Pfizer, Takeda, Sun Pharma).