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Norepinephrine-stimulated HSCs secrete sFRP1 to promote HCC progression following chronic stress via augmentation of a Wnt16B/β-catenin positive feedback loop

Crossref DOI link: https://doi.org/10.1186/s13046-020-01568-0

Published Online: 2020-04-15

Published Print: 2020-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Lin, Xia-Hui

Liu, Hua-Hua

Hsu, Shu-Jung

Zhang, Rui

Chen, Jie

Chen, Jun

Gao, Dong-Mei

Cui, Jie-Feng

Ren, Zheng-Gang

Chen, Rong-Xin
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (81472217, 81972715)
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Text and Data Mining valid from 2020-04-15

Version of Record valid from 2020-04-15
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Article History

Received: 11 February 2020

Accepted: 2 April 2020

First Online: 15 April 2020

Ethics approval and consent to participate

: The study was approved by the Zhongshan Hospital Research Ethics Committee, and written informed consent obtained from each patient. All animal experiments were approved by the Ethical Committee on Animal Experiments of Animal Care Committee of Zhongshan Hospital of Fudan University, Shanghai, China and carried out according to the Shanghai Medical Experimental Animal Care Commission Guidelines.

: Not applicable.

: The authors declare that they have no conflict of interests.

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