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Circulating extracellular vesicles from individuals at high-risk of lung cancer induce pro-tumorigenic conversion of stromal cells through transfer of miR-126 and miR-320

Crossref DOI link: https://doi.org/10.1186/s13046-021-02040-3

Published Online: 2021-07-21

Published Print: 2021-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Pontis, Francesca

Roz, Luca

Mensah, Mavis

Segale, Miriam

Moro, Massimo

Bertolini, Giulia

Petraroia, Ilaria

Centonze, Giovanni

Ferretti, Anna Maria

Suatoni, Paola

Pastorino, Ugo

Fortunato, Orazio

Sozzi, Gabriella
Funding

Funding for this research was provided by:

Associazione Italiana per la Ricerca sul Cancro (14318 and 18812, IG21431)

Ministero della Salute (RF-2016-02362946)

Fondazione Cariplo (2015-0901)
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Text and Data Mining valid from 2021-07-21

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Article History

Received: 31 March 2021

Accepted: 12 July 2021

First Online: 21 July 2021

Declarations

:

: Plasma samples were collected from high-risk heavy-smoker volunteers (age 50–75 years), including current or former smokers with a minimum pack/year index of 30 enrolled in a LDCT screening trial performed at our institution (BioMild Trial, ClinicalTrials.gov: NCT02247453)[]. EVs were also isolated from the plasma of lung cancer patients affered to Thoracic Unit of our Institute. Plasma collection was approved by the Internal Review and the Ethics Boards of the Istituto Nazionale Tumori (INT 11–21) of Milan. All patients provided informed consent.

: All authors involved in the study had given their consent for submitting this article for publication.

: The authors declare no conflicts of interest.

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