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Colorectal cancer development is affected by the ECM molecule EMILIN-2 hinging on macrophage polarization via the TLR-4/MyD88 pathway

Crossref DOI link: https://doi.org/10.1186/s13046-022-02271-y

Published Online: 2022-02-11

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Andreuzzi, Eva http://orcid.org/0000-0002-5925-5230
Fejza, Albina http://orcid.org/0000-0003-2131-5151
Polano, Maurizio http://orcid.org/0000-0002-6101-1382
Poletto, Evelina http://orcid.org/0000-0001-5675-3026
Camicia, Lucrezia http://orcid.org/0000-0002-0154-6182
Carobolante, Greta

Tarticchio, Giulia

Todaro, Federico

Di Carlo, Emma http://orcid.org/0000-0001-7778-1042
Scarpa, Melania http://orcid.org/0000-0002-7055-635X
Scarpa, Marco http://orcid.org/0000-0002-0217-6523
Paulitti, Alice http://orcid.org/0000-0002-7596-2605
Capuano, Alessandra http://orcid.org/0000-0002-5443-0570
Canzonieri, Vincenzo http://orcid.org/0000-0001-6010-0976
Maiero, Stefania http://orcid.org/0000-0001-5085-1549
Fornasarig, Mara http://orcid.org/0000-0003-3388-0676
Cannizzaro, Renato http://orcid.org/0000-0002-2020-222X
Doliana, Roberto http://orcid.org/0000-0002-8324-7564
Colombatti, Alfonso http://orcid.org/0000-0002-3676-2379
Spessotto, Paola http://orcid.org/0000-0002-3033-404X
Mongiat, Maurizio http://orcid.org/0000-0001-6509-0068
Funding

Funding for this research was provided by:

Ministero della Salute (RF-2010-2312580, RF-2018-12365425)

Associazione Italiana per la Ricerca sul Cancro (IG-12718, IG-23643, IG-23264)

Ministero dell’Istruzione, dell’Università e della Ricerca (2017M8YMR8)
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Article History

Received: 27 September 2021

Accepted: 22 January 2022

First Online: 11 February 2022

Declarations

:

: For this study 23 patients with colorectal cancer were consecutively enrolled. Written informed consent was obtained from each patient on the day of the procedure. The methodologies complied with the standards set by the Declaration of Helsinki. This study was approved by the Institutional Ethical Board of CRO-IRCCS of Aviano (PN), Italy (IRB no. CRO-2014-03). The pathological features were retrieved from the Hospital database.All the preclinical studies were approved by the Institutional Ethics Committee of the CRO-IRCCS of Aviano and the Italian Ministry of Health (Project License: 148/2016 PR) and adhered to ARRIVE guidelines.

: Not applicable.

: The authors declare that they have no competing interests.

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