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The immune microenvironment of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma: a multiparametric quantitative and spatial analysis unveils a rationale to target treatment-naïve tumors with immune checkpoint inhibitors

Crossref DOI link: https://doi.org/10.1186/s13046-022-02481-4

Published Online: 2022-09-20

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Tosi, Anna

Parisatto, Beatrice

Menegaldo, Anna

Spinato, Giacomo

Guido, Maria

Del Mistro, Annarosa

Bussani, Rossana

Zanconati, Fabrizio

Tofanelli, Margherita

Tirelli, Giancarlo

Boscolo-Rizzo, Paolo

Rosato, Antonio https://orcid.org/0000-0002-5263-8386
Funding

Funding for this research was provided by:

Fondazione AIRC (ID. 21354 project)

5 per Mille 2019 (- ID. 22759 program)

5 per Mille 2019, Veneto Institute of Oncology IOV-IRCCS (BIOV19ROSATO)

the Ministry of Health-Alliance Against Cancer (RCR-2019-23669115, WG6-ACC-2020)
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Text and Data Mining valid from 2022-09-20

Version of Record valid from 2022-09-20
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Article History

Received: 24 June 2022

Accepted: 30 August 2022

First Online: 20 September 2022

Declarations

:

: The study was approved by the ethic committees for clinical experimentation (CEP) of Treviso and Belluno provinces (Ethic votes: 345/AULSS9 and 421/AULSS9) and Friuli Venezia Giulia region (Ethic votes: CEUR-Os-041-ASUITS), and all patients signed an informed consent.

: All authors agreed with submission of the manuscript for publication and agree to be accountable for all aspect of the manuscript.

: The authors declare that they have no competing interests.

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