Genta, Sofia
Lajkosz, Katherine
Yee, Noelle R.
Spiliopoulou, Pavlina
Heirali, Alya
Hansen, Aaron R.
Siu, Lillian L.
Saibil, Sam
Stayner, Lee-Anne
Yanekina, Maryia
Sauder, Maxwell B.
Keshavarzi, Sareh
Salawu, Abdulazeez
Vornicova, Olga
Butler, Marcus O.
Bedard, Philippe L.
Razak, Albiruni R. Abdul
Rottapel, Robert
Chruscinski, Andrzej
Coburn, Bryan
Spreafico, Anna
Funding for this research was provided by:
Novartis Young Canadian Investigator Award
Dr. Spreafico Research Found
Article History
Received: 22 June 2023
Accepted: 5 October 2023
First Online: 21 October 2023
Declarations
:
: The INSPIRE (NCT02644369) and MET4-IO (NCT03686202) trials were investigator-initiated studies, approved by the Princess Margaret Cancer Centre Research Ethics Board (#18–5950 and 15–9828). All the patients signed informed consent for the participation in the INSPIRE or MET4-IO studies. Samples obtained from the participants were used for this correlative study without interfering with the primary objectives of the two clinical trials.
: All the authors approved the current version of the manuscript and agree with publication.
: The following authors have conflicts of interest to declare:Anna Spreafico:Consultant for (Advisory Board): Merck (compensated), Bristol-Myers Squibb (compensated), Oncorus (compensated), Janssen (compensated), Medison & Immunocore (compensated);Grant/Research support from (Clinical Trials): Novartis, Bristol-Myers Squibb, Symphogen AstraZeneca/Medimmune, Merck, Bayer, Surface Oncology, Northern Biologics, Janssen Oncology/Johnson & Johnson, Roche, Regeneron, Alkermes, Array Biopharma/Pfizer, GSK, NuBiyota, Oncorus, Treadwell, Amgen.Lillian L. Siu:Consultant for (Advisory Board): Merck, Pfizer, AstraZeneca, Roche, GlaxoSmithKline, Voronoi, Arvinas, Tessa, Navire, Relay, Rubius, Daiichi Sanyko, Coherus, Marengo, InteRNA, Tubulis, LTZ Therapeutics, NGM Biotherapeutics.Stock ownership: Agios (spouse);Leadership position: Treadwell Therapeutics (spouse);Grant/Research support from (Clinical Trials): Novartis, Bristol-Myers Squibb, Pfizer, Boerhinger-Ingelheim, GlaxoSmithKline, Roche/Genentech, AstraZeneca, Merck, Celgene, Astellas, Bayer, Abbvie, Amgen, Symphogen, Shattucks, BionTech, 23Me, EMD Serono.Pavlina Spilopoulou:Honorarium: Pfizer.