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Article History

Received: 20 December 2023

Accepted: 9 February 2024

First Online: 27 February 2024

Declarations

:

: The collection of patient data and tissue for the generation of organoids has been performed according to the guidelines of the European Network of Research Ethics Committees (EUREC) following European, national, and local law. This research was performed under the HUB-Cancer biobanking protocol and OPTIC protocol. The Biobank Research Ethics Committee of the UMC Utrecht (TCBio) approved the biobanking protocol: 12–093 HUB-Cancer. The medical ethical committee of the University Medical Center Utrecht (UMCU) approved the prospective clinical trial Organoids to Predict Therapy Response In Colorectal Cancer (OPTIC #17–356 [CitationRef removed]). All donors participating in this study signed informed consent. The study was performed in accordance with the Declaration of Helsinki.

: Not applicable.

: Miriam Koopman reports institutional financial interests with Amgen, Bayer, Bristol-Myers Squibb, Merck-Serono, Nordic Pharma, Pierre Fabre, Servier, Sirtex, Roche, Sanofi, and Personal Genome Diagnostics. Miriam Koopman reports the following non-financial interests: an advisory role for ZON-MW, membership of the scientific board of the Dutch Cancer Society (KWF), chairmanship of the Dutch Colorectal Cancer Group (DCCG), and principal investigator (PI) of the Prospective Dutch Colorectal Cancer (PLCRC) cohort. Jeanine Roodhart reports institutional financial interests with BMS, Pierre Fabre, Servier, Cleara, Xilis, DoMore diagnostics and HUB organoids B.V. Jeanine Roodhart reports an advisory role for Bayer, BMS, Merck-Serono, Pierre Fabre, Servier, AMGEN and board member of Foundation Hubrecht Organoid Biobank. Liselot Valkenburg-van Iersel reports financial interests with and an advisory role for Servier and Pierre Fabre. All other authors declare that they have no competing interests.