Document is current
Any future updates will be listed below
-
Authors
Di Pompo, Gemma
Mitsiadis, Thimios A.
Pagella, Pierfrancesco
Pasquarelli, Alessandro
Bettini, Giuliano
Sabattini, Silvia
Righi, Alberto
Avnet, Sofia
Baldini, Nicola
-
Funding
Funding for this research was provided by:
Fondazione AIRC per la ricerca sul cancro (AIRC (IG 2018—ID. 21403 project “Altered lipid metabolism as a stress reaction to acid tumour microenvironment and a driver of metastasis in osteosarcoma” to N.B.))
Italian Ministry of Health ((5 × 1000 Anno 2022, Redditi 2021, 5M-2022-23685324, CUP D33C23001460001 “Modelli tridimensionali di tumori ossei per migliorare l'efficacia di studi preclinici in vitro” to N.B))
- License Information
-
More Information
Article History
Received: 24 March 2025
Accepted: 25 August 2025
First Online: 30 September 2025
Declarations
:
: The clinical study on canine OS is a retrospective study on archived FFPE tissue samples. As the research did not influence any therapeutic decision, approval by an ethics committee was not required. However, all diagnostic and therapeutic procedures were performed in accordance with the Public Health Service Policy on Humane Care and Use of Laboratory Animals. All the examined samples were collected for diagnostic purposes as part of routine standard care. Owners gave informed consent to the use of clinical data and stored biological samples for teaching and research purposes. The retrospective clinical study for the sampling of human OS tissues was approved by the Ethics Committee (local Ethics Committee, approval No. 184, 07/01/2015). The prospective clinical study for the not-transformed bone tissue was approved by the Ethics Committee (CE-AVEC 586/2020/Sper/IOR, approval No. 0009411, 06/07/2020). For both studies, participants provided written informed consent.
: All authors agree to submit the article for publication.
: The authors declare no competing interests.
