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Authors
Zhu, Junyao https://orcid.org/0009-0009-5075-6619
Dai, Xinyi
Ghosh, Santanu
Wei, Elaine
Mao, Chengjian
Jiang, Qianjin
Spaulding, Abigail J.
Mulligan, Michael P.
Romero, Roger
Han, Yoo Jane
Boudreau, Matthew W.
Olopade, Olufunmilayo
Hergenrother, Paul J.
Shapiro, David J.
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Funding
Funding for this research was provided by:
National Cancer Institute (R01CA258746, RO1CA265333)
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Article History
Received: 29 July 2025
Accepted: 8 October 2025
First Online: 13 November 2025
Declarations
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: The ethics approvals of the mouse study and use of patient-derived organoids are described in the Materials and Methods section.
: All authors have agreed to publish this manuscript.
: The authors declare no competing interests.
: The Univ. of Illinois has filed patent applications on some compounds described here on which DJS, MWB, and PJH are co-inventors (US Patent 12, 180. 159; U.S. Patent Application No. 63/055,583). Some compounds described herein have been licensed to Systems Oncology. PJH is a consultant for Systems Oncology and is on the Systems Oncology SAB.
