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Authors
Allegretti, Matteo https://orcid.org/0000-0003-3398-8775
Joun, David J.
Urbani, Giulia https://orcid.org/0009-0009-1343-3415
De Pascale, Valentina https://orcid.org/0000-0003-1015-8867
Ganci, Federica https://orcid.org/0000-0002-8010-2183
Pellini, Raul https://orcid.org/0000-0001-6051-3041
Beltramini, Giada Anna https://orcid.org/0000-0002-4351-0276
Ferrero, Stefano https://orcid.org/0000-0002-3715-0737
Fiori, Stefano
Moccia, Tania https://orcid.org/0000-0002-0463-9552
Ciardiello, Chiara https://orcid.org/0000-0003-2042-8672
Di Gennaro, Elena https://orcid.org/0000-0001-6223-7845
Budillon, Alfredo https://orcid.org/0000-0002-6330-6053
Sigalotti, Luca https://orcid.org/0000-0002-1436-2358
Maestro, Roberta https://orcid.org/0000-0002-6642-5592
Urtis, Mario https://orcid.org/0000-0003-3289-9228
Arbustini, Eloisa https://orcid.org/0000-0003-2948-7994
De Summa, Simona https://orcid.org/0000-0001-9607-3754
Azzariti, Amalia https://orcid.org/0000-0002-6149-5049
Gagliardi, Stella https://orcid.org/0000-0002-6589-6907
Pisani, Antonio
Ciliberto, Gennaro https://orcid.org/0000-0003-2851-8605
Muti, Paola Cornelia Maria https://orcid.org/0000-0003-0339-8520
Stevens, Junko F.
Blandino, Giovanni https://orcid.org/0000-0002-6970-2241
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Funding
Funding for this research was provided by:
Ministero della Salute (PNC E3-2022-23683266)
Fondazione AIRC per la ricerca sul cancro ETS (IG 29040)
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Article History
Received: 15 September 2025
Accepted: 13 November 2025
First Online: 20 December 2025
Declarations
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: FFPE samples including matched tumors and peritumoral area were obtained from Policlinico of Milan (EC authorization #105/IRE/24). Additional tumor specimens, sera and saliva were also collected from the IRCCS Regina Elena National Cancer Institute biobank (EC authorization #RS868/16). A written informed consent was collected from all human subjects involved in this study.
: Not applicable.
: MA, GU, VDP, FG, RP, GB, SF, SF, TM, CC, EDG, AB, LS, RM, MU, EA, SDS, AA, SG, AP, GC and GB declare no potential conflicts of interest with the present work. DJJ and JFS are employees of Thermo Fisher Scientific. miRquad assay content is based on a previously patented set of miRNA targets registered by GB, FG, and RP (#102020000019024).
