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Human endogenous retrovirus-K envelope protein is aberrantly expressed in serous ovarian cancer and promotes chemosensitivity via NF-κB/P-glycoprotein pathway inhibition

Crossref DOI link: https://doi.org/10.1186/s13048-025-01722-2

Published Online: 2025-07-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Nguyen, Que Thanh Thanh

Shin, Soo-Gui

Nguyen, Tra Tran Thu

Lee, Kyoung Yul

McClelland, Michael

Lee, Eun-Ju https://orcid.org/0000-0001-9446-1059
Funding

Funding for this research was provided by:

National Research Foundation of Korea (NRF) grant funded by the Korean government (RS-2024-00412879RS-2024-00412879)

the Basic Science Research Program through the National Research Foundation of Korea (2020R1A2C1003536)
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Article History

Received: 19 February 2025

Accepted: 9 June 2025

First Online: 4 July 2025

Declarations

:

: In the retrospective clinical study, consent exemption was approved by the Institutional Review Board of Chung-Ang University Hospital (approval number: 2051-007-421; approval date: February 16, 2021). Anonymized and stored cDNA from ovarian cancer tissue was used with approval of the Institutional Review Board in Chung-Ang University Hospital (approval number: 2109-004-476).

: Not applicable.

: The authors declare no competing interests.

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