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Article History

Received: 16 December 2024

Accepted: 7 March 2025

First Online: 18 March 2025

Declarations

:

: The Danish Research Ethics Committee (H-21018062) and the Danish Medicines Agency (EudraCT 2021-000556-19) approved the TRAUMOX2 trial, which was also registered in the Capital Region of Denmark data controller’s register (P-2021-476), and at ClinicalTrials.gov (NCT05146700). Additional approvals, not relevant to this substudy, were also obtained.

: Not applicable.

: Tobias Arleth: Received funding for a biomarker Copenhagen substudy of TRAUMOX2 from the Holger and Ruth Hesses Memorial Foundation and Danish Air Ambulance, and received funding for three months of research PhD programme exchange from Knud Højgaard’s Foundation, the William Demant Foundation, and Ottilia Brorson’s Travel Scholarships, the Medical Science Faculty Foundation of Copenhagen University, and the Consultant Dr. Med. Edgar Schnohr and wife Gilberte Schnohrs Foundation. All grants were received outside the submitted work. Josefine Baekgaard: Received funding for the TRAUMOX2 trial from the Novo Nordisk Foundation. She was also awarded a prize for “Talented Young Researcher” by the Lundbeck Foundation from which €47,000 was allocated to research, with some of the money spent on this trial. Stine Zwisler: Attended a Secma ultrasound course in Italy (March 2024), where Secma paid for the trip, and no payment was made to her or her organization. Markus Klimek: Received grants to organization for research laboratory Music as Medicine; honoraria from Paion as a member of the data safety board and Tijdstroom Uitgeverij for serving as an editor of a Dutch textbook; and serving as a course director for Advanced Trauma Life Support outside the submitted work. Jacob Steinmetz: Received funding of his professorship to his institution from the Norwegian Air Ambulance foundation. The remaining authors (OR, AC, LBP, SM, LSR) declare to have potential conflicts of interest.