Document is current

Article History

Received: 25 March 2018

Accepted: 16 October 2018

First Online: 21 December 2018

Authors’ information

: <b>Sponsor</b>sphingotec GmbHNeuendorfstraße 15a16761 HennigsdorfGermany<b>Principal investigators</b>Prof. Dr. Alexandre Mebazaa, HeadDepartment of Anesthesiology and Critical Care MedicineAP-HP, Saint Louis and Lariboisière University HospitalsParis, FranceTel: + 33 1 49 95 80 83Fax: + 33 1 49 95 80 71Prof. Pierre-François Laterre, Head of Clinical ServiceSaint Luc University Hospital at the Université Catholique de LouvainBrussels, BelgiumTel: + 32 2764 27 35Fax: + 32 2764 89 28

: The present study was conducted in France, Belgium, The Netherlands, Italy, and Germany. The study protocol was approved by the local ethics committees, and the study was conducted in accordance with Directive 2001/20/EC as well as good clinical practice (International Conference on Harmonization Harmonized Tripartite Guideline version 4 of May 1, 1996, and decision of November 24, 2006) and the Declaration of Helsinki. Patients were included from June 2015 to May 2016.

: Not applicable.

: AM has received speaker’s honoraria from Novartis, Orion, and Servier and fees as a member of the advisory board and/or steering committee from Cardiorentis, Adrenomed, sphingotec, Sanofi, Roche, Abbott, and Bristol-Myers Squibb. EG has received consulting fees from Adrenomed, Roche Diagnostics, and Magnisense and lecture fees from Edwards Lifesciences. AB is the managing director of sphingotec GmbH and holds shares in it. OH and JS are employees of sphingotec GmbH, the company that developed and holds patent rights in the bio-ADM assay. BF has received consulting fees from Aridis, Ferring, Arsanis, Inotrem, and Lascco. PP serves as a consultant for and has received consulting fees from Adrenomed. The other authors report no conflicts of interest. ML has received lecture fees from Alere, Fresenius, and Gilead Sciences and consulting fees from Adrenomed. PFL has received consulting fees from Adrenomed, Ferring, and Lascco. The other authors report no conflicts of interest.

: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.