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Article History

Received: 9 March 2021

Accepted: 25 May 2021

First Online: 31 May 2021

Declarations

:

: The SAPPHIRE study protocol was approved by the Western Institutional Review Board (Olympia, Washington, USA) and by each investigational review/ethics boards/committees at each participating institution, as required. All enrolled patients or their legally authorized representatives provided written informed consent.

: Not applicable.

: SMB discloses consulting fees and grant support from Baxter and consulting fees from CNA Diagnostics. AAK, AA and DD have nothing to disclose. MH discloses consulting fees from Abbott outside the present analysis. ML discloses research grant funding from Prescient Healthcare, LLC as well as grant support from Astute Medical/ bioMérieux outside of the present analysis. KZ received grants from B. Braun Melsungen, CSL Behring, Fresenius Kabi, and Vifor Pharma for the implementation of Frankfurt's Patient Blood Management program and honoraria for scientific lectures from B. Braun Melsungen, Vifor Pharma, Ferring, CSL Behring, and Pharmacosmos outside the present analysis. LSC reports receiving consulting fees from Astute Medical/ bioMérieux. TK, JPK and PM are employees of Astute Medical/ bioMérieux. JAK discloses consulting fees and grant support from Astute Medical/bioMérieux outside the present analysis.