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Authors
Hørsdal, Oskar Kjærgaard https://orcid.org/0000-0003-1009-3768
Ellegaard, Mark Stoltenberg https://orcid.org/0009-0000-9279-6269
Larsen, Alexander Møller https://orcid.org/0009-0000-4459-4291
Guldbrandsen, Halvor https://orcid.org/0000-0003-0820-8247
Moeslund, Niels https://orcid.org/0000-0003-0827-5263
Møller, Jacob Eifer https://orcid.org/0000-0003-2873-5845
Helgestad, Ole Kristian Lerche https://orcid.org/0000-0003-3847-8758
Ravn, Hanne Berg https://orcid.org/0000-0003-4702-5195
Wiggers, Henrik https://orcid.org/0000-0002-9753-4142
Nielsen, Roni https://orcid.org/0000-0001-9228-3869
Gopalasingam, Nigopan https://orcid.org/0009-0006-6363-7406
Berg-Hansen, Kristoffer https://orcid.org/0000-0002-5110-0656
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Funding
Funding for this research was provided by:
Novo Nordisk
Aase og Ejnar Danielsens Fond
Snedkermester Sophus Jacobsen og Hustru Astrid Jacobsens Fond
Sundhedsvidenskabelige Fakultet, Aarhus Universitet
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Article History
Received: 10 January 2025
Accepted: 27 February 2025
First Online: 14 March 2025
Declarations
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: The study was conducted after obtaining the necessary authorization from the Danish National Animal Experiment Inspectorate. (Hemodynamic Optimization with Carbonates, Permit no: 2023-15-0201-01466, issued on 19/06-2023). The treatment administered and ethical oversight concerning the animals strictly adhered to established animal welfare protocols and regulatory standards mandated by both Danish and European legislation. The methodologies employed and the handling of animals conformed to the guidelines outlined in the EU Directive 2010/63/EU pertaining to animal experimentation.
: Not applicable.
: Roni Nielsen has collaboration with the pharceutical companies Imbria, Medtrace, Resother as an investigation and has received lectural fee from Astrazeneca. Roni Nielsen is a patentholderof 20205938.2 A Lactate/Ketone Body ester, 5-11-2020. Henrik Wiggers has been the principal or a sub-investigator in studies involving the following pharmaceutical companies: MSD, Bayer, Daiichi-Sankyo, Novartis, Novo Nordisk, Sanofi-Aventis, and Pfizer.
: In this experimental study in ischemic cardiogenic shock in human-sized pigs by @OHorsdal et al, infusion with #lactate increased cardiac output due to increased stroke volume. Contractility was increased and mitochondrial function was enhanced during lactate infusion.
