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Authors
Zampieri, Fernando G.
Azevedo, Luciano C. P.
Neto, Ary Serpa
Rea-Neto, Álvaro
David-João, Paula G.
Amendola, Cristina P.
Kozesinski-Nakatani, Amanda C.
Filiponi, Thiago C.
Almeida, Guacyra M. B.
Bergo, Ricardo R.
Figueiredo, Rodrigo C.
Schuler, Clewer J.
Westphal, Glauco A.
Biondi, Rodrigo S.
Pereira, Adriano J.
Correa, Thiago D.
Berwanger, Otavio
Bagshaw, Sean M.
Bellomo, Rinaldo
Tavares, Caio A. M.
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Funding
Funding for this research was provided by:
PROADI-SUS
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Article History
Received: 21 April 2025
Accepted: 29 June 2025
First Online: 11 July 2025
Declarations
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: The DEFENDER clinical trial was approved by Brazilian National ethics committee and locally at each site by the ethical board.
: All authors consent publication of the available results.
: The authors declare no competing interests.
