Meyer, Martin A. S.
Beske, Rasmus P.
Mølstrøm, Simon
Grand, Johannes
Obling, Laust E. R.
Wiberg, Sebastian
Borregaard, Britt
Schneekloth, Simon
Kaad, Sif Grau
Christensen, Pernille M.
Christoffersen, Christina
Frikke-Schmidt, Ruth
Schmidt, Henrik
Møller, Jacob E.
Kjaergaard, Jesper
Hassager, Christian
Funding for this research was provided by:
Copenhagen University
Article History
Received: 6 June 2025
Accepted: 18 July 2025
First Online: 6 August 2025
Declarations
:
: The BOX trial was approved by the regional ethics committee of the Capital Region of Denmark prior to initiation (Approval no. H-16033436). Inclusion of incapacitated patients was performed after consent from a trial guardian in the acute setting in accordance with Danish legislation. Relatives were asked for consent as soon as possible, and patients who regained consciousness were also asked for consent.
: Not applicable.
: The authors declare no competing interests.