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Cleavage of the extracellular domain of junctional adhesion molecule-A is associated with resistance to anti-HER2 therapies in breast cancer settings

Crossref DOI link: https://doi.org/10.1186/s13058-018-1064-1

Published Online: 2018-11-20

Published Print: 2018-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Leech, Astrid O.

Vellanki, Sri HariKrishna

Rutherford, Emily J.

Keogh, Aoife

Jahns, Hanne

Hudson, Lance

O’Donovan, Norma

Sabri, Siham

Abdulkarim, Bassam

Sheehan, Katherine M.

Kay, Elaine W.

Young, Leonie S.

Hill, Arnold D. K.

Smith, Yvonne E.

Hopkins, Ann M. https://orcid.org/0000-0003-2836-6584
Funding

Funding for this research was provided by:

Science Foundation Ireland (13/IA/1994)

Breast Cancer Ireland

Health Research Board (HRA-POR-2014-545)

Beaumont Hospital Cancer Research and Development Trust
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Article History

Received: 21 December 2017

Accepted: 18 October 2018

First Online: 20 November 2018

Ethics approval and consent to participate

: Ethical approval for the use of patient blood and tissue samples from Beaumont Hospital was obtained from the Beaumont Hospital Medical Ethics (Research) Committee (07/74; investigators ADKH and LSY) and Cancer Trials Ireland (ICORG 09/07).

: Not applicable.

: The authors declare that they have no competing interests.

: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.