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Article History

Received: 15 October 2018

Accepted: 15 May 2019

First Online: 5 July 2019

Ethics approval and consent to participate

: This clinical trial was conducted in accordance with Good Clinical Practice guidelines. Approval for the protocol was obtained from the institutional review board for The University of Texas MD Anderson Cancer Center, Dana Farber Cancer Institute, Columbia University, and Vanderbilt University. All participants gave informed consent before they entered the study.

: All authors agreed to this publication.

: V. Abramson, A. Akcakanat, H. Chen, K-A Do, L.A. Doyle, A.K Eterovic, A.M. Gonzalez-Angulo, G.M. Wulf, L. Yisheng, A. Mahvash, D. Riall, A. Sahin, E. Tarco, V. Valero, Y. Xing have nothing to disclose.L. C. Cantley reports grants from NCI, Stand Up To Cancer/AACR, Breast Cancer Research Foundation, and the Jon and Mindy Gray Foundation during the conduct of this study. He has a patent: improving responses to cancer drugs by dietary and pharmaceutical interventions that lower serum insulin pending. He is a founder and member of the SAB of Agios Pharmaceuticals and of Petra Pharmaceuticals. These companies are developing novel therapies for cancer. His laboratory also receives some financial support from Petra Pharmaceuticals.M. Chavez-MacGregor reports grant from Novartis and consulting fees from Roche and Pfizer.D. Hong reports grants from Merck, Daichii-Sanko, Eisai, Adaptimmune, Abbvie, Astra-Zeneca, BMS, Genmab, infinity, Kite, Kyowa, Medimmune, Molecular Template, Novartis, and Takeda, and personal fees from Mima, LOXO, Bayer, Baxter, Guidepoint Global, Oncoresponse, Takeda, Janssen, and Molecular Match.R. Hortobagyi reports grants from Merck.N.U. Lin reports grants from Pfizer, Genentech/Roche, Kadmon, Novartis, and Array Biopharma, and personal fees from Genentech, Shionogi Inc., Seattle Genetics, and Daichii.J. Litton reports grants from Pfizer, Astra Zeneca, Genentech, EMD Serono, and GSK.M.A. Mauer is a fulltime employee of Bristol Myers-Squibb. His work at BMS has no direct relationship to the work in this study.F. Meric-Bernstam reports receiving commercial research grants from Novartis, AstraZeneca, Calithera, Aileron, Bayer, Jounce, CytoMx, eFFECTOR, Zymeworks, PUMA Biotechnology, Curis, Millennium, Daiichi Sankyo, Abbvie, Guardant Health, Takeda, and GlaxoSmithKline as well as grants and travel-related fees from Taiho, Genentech, Debiopharm Group, and Pfizer. She also served as a consultant to Pieris, Dialectica, Sumitomo Dainippon, Samsung Bioepis, Aduro, OrigiMed, Xencor, and Jackson Laboratory, and advisor to Inflection Biosciences, GRAIL, Darwin Health, Clearlight Diagnostics, Spectrum, and Mersana.G.B. Mills reports grants from Adelson Medical Research Foundation, AstraZeneca, Breast Cancer Research Foundation, Immunomet, Ionis, KarusTherapeutics, Komen Research Foundation,Nanostring, Ovarian Cancer Research Foundation, Pfizer, Prospect Creek Foundation, and Takeda/Millennium Pharmaceuticals; personal fees from AstraZeneca, Catena Pharmaceuticals, Critical Outcome Technologies, ImmunoMET, Ionis, SignalchemLifesciences, Symphogen, Takeda/Millennium Pharmaceuticals, and Tarveda; stock/financial interest in Catena Pharmaceuticals, ImmunoMet, SignalChem, Spindle Top Ventures, and Tarveda; and licensed technology in HRD assay to Myriad Genetics.S.A. Piha-Paul reports grants from Merck Sharp & Dohme Corp, Genmab, Taiho Oncology, Medimume, LLC, BioMarin Pharmaceutical, Inc., Novartis Pharmaceuticals, Principia Biopharma, Inc., Abbvie, Merck, Pieris Pharmaceuticals, Inc., Puma Biotechnology, Inc., GlaxoSmithKline, Helix BioPharma Corp, Curis, Tesaro, and Medivation.E. Winer reports personal fees from Genentech, Leap, InfiniteMD, Lilly, Carrick Therapeutics, GSK, and Verastem.

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