Graeser, Monika http://orcid.org/0000-0003-1916-717X
Schrading, Simone
Gluz, Oleg
Strobel, Kevin
Herzog, Christopher
Umutlu, Lale
Frydrychowicz, Alex
Rjosk-Dendorfer, Dorothea
Würstlein, Rachel
Culemann, Ralph
Eulenburg, Christine
Adams, Jascha
Nitzsche, Henrik
Prange, Anna
Kümmel, Sherko
Grischke, Eva-Maria
Forstbauer, Helmut
Braun, Michael
Potenberg, Jochem
von Schumann, Raquel
Aktas, Bahriye
Kolberg-Liedtke, Cornelia
Harbeck, Nadia
Kuhl, Christiane K.
Nitz, Ulrike
Funding for this research was provided by:
Bayer
F. Hoffmann-La Roche
Celgene
Teva Pharmaceutical Industries
Universität Hamburg
Article History
Received: 30 July 2020
Accepted: 24 February 2021
First Online: 18 March 2021
Declarations
:
: The ADAPT study was performed in accordance with the Declaration of Helsinki. The substudy protocols were approved by the Ethics Committee of the Medical Faculty of the University of Cologne, Germany (approval number: 11-283), and national authorities. Written informed consent was obtained from each patient prior to study participation.
: Not applicable.
: MG received honoraria from AstraZeneca and travel support from Daiichi Sanyko.OG has an ownership interest in WSG GmbH; received honoraria from Genomic Health, Roche, Celgene, Pfizer, Novartis, NanoString Technologies, and AstraZeneca; served in consulting/advisory role for Celgene, Exact Sciences, Lilly, MSD Brazil, Novartis pharma SAS, Pfizer Pharmaceuticals Israel, and Roche; and received travel support from Roche.LU received honoraria, travel support and served in consulting/advisory role for Siemens Healthcare, Bayer Healthcare, and received research funding from Siemens Healthcare.RW served in consulting/advisory role and received travel support from Agendia, Amgen, Aristo, AstraZeneca, Boeringer Ingelheim, Carl Zeiss, Celgene, Clinsol, Daiichi-Sankyo, Esai, Genomic Health, Glaxo Smith Kline, Hexal, Lilly, Medstrom Medical, MSD, Mundipharma, Nanostring, Novartis, Odonate, Paxman, Palleos, Pfizer, Pierre Fabre, PumaBiotechnolgogy, Riemser, Roche, Sandoz/Hexal, Seattle Genetics, Tesaro Bio, and Teva.JA is an employee of Alcedis GmbH, Giessen, Germany.SK has an ownership interest in WSG GmbH; served in consulting/advisory role for Roche, Genomic Health, Novartis, AstraZeneca, Amgen, Celgene, SOMATEX Medical Technologies, Daiichi Sankyo, pfm medical, Pfizer, MSD, Lilly, and Sonoscape; and received travel support from Roche, Daiichi Sankyo, and Sonoscope.HF received honoraria and travel support and served in consulting/advisory role for Roche, Celgene.MB received honoraria from AstraZeneca, Exact Sciences, Novartis, Pfizer, Roche, Teva, travel support from AstraZeneca, Celgene, Medac, Novartis, and Roche and served in consulting/advisory role for AstraZeneca, Exact Sciences, Novartis, Puma, and Roche.BA received honoraria from Pfizer, Roche Pharma, Novartis Pharma, AstraZeneca, Amgen, Tesaro Bio Germany, PharmaMar, and Eisei; served in consulting/advisory role for Novartis Pharma, Roche Pharma, Pfizer, and Tesaro Bio; and received travel support from AstraZeneca, Amgen, Roche Pharma, Pfizer, Novartis Pharma, Tesaro Bio Germany, PharmaMar, and Eisei.CKL has an ownership interest in Theraklion and Phaon Scientific; received honoraria from Roche, AstraZeneca, Celgene, Novartis, Pfizer, Lilly, Hexal, Amgen, SonoScape, Pfizer, Novartis, Roche, Genomic Health, Amgen, AstraZeneca, Riemser, Carl Zeiss MediTec, TEVA Pharmaceuticals Industries, Theraklion, Janssen-Cilag, GlaxoSmithKline, and LIV Pharma; served in consulting/advisory role for Roche, Novartis, Pfizer, Celgene, Phaon Scientific, Pfizer, Novartis, SurgVision, CarlZeissMeditec, Amgen, and Onkowissen; received research funding from Roche, Novartis, and Pfizer; and received travel support from Roche, Daiichi Sankyo, Novartis, Carl Zeiss Meditec, LIV Pharma, Novartis, Amgen, Pfizer, and Daiichi Sankyo.NH has an ownership interest in WSG GmbH; received honoraria from Amgen, AstraZeneca, Genomic Health, Novartis, Pfizer, Pierre Fabre, Roche, and Zodiac Pharma; served in consulting/advisory role for Agendia, AstraZeneca, Celgene, Daiichi Sankyo, Lilly, Merck Sharp & Dohme, Novartis, Odonate Therapeutics, Pfizer, Pierre Fabre, Roche/Genentech, Sandoz, Seattle Genetics, and West German Study Group; and received research funding from Lilly, Merck Sharp & Dohme, Novartis, Pfizer, and Roche/Genentech.CKK received honoraria from Bayer Healthcare.UN has an ownership interest in WSG GmbH; received honoraria from Agendia, Amgen, Celgene, Genomic Health, NanoString Technologies, Novartis pharma SAS, Pfizer Pharmaceuticals Israel, Roche/Genentech, and Teva; served in consulting/advisory role for Genomic Health and Roche; received research funding from Agendia, Amgen, Celgene, Genomic Health, NanoString Technologies, Roche, and Sanofi; provided expert testimony for Genomic Health; and received travel support from Genomic Health, Pfizer Pharmaceuticals Israel, and Roche.