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Article History

Received: 24 January 2023

Accepted: 25 July 2023

First Online: 4 August 2023

Declarations

:

: The mice used in this project have been allocated at the Animal Facility of the Spanish National Cancer Research Center (CNIO, Madrid) and the Faculty of Biology at Complutense University (UCM, Madrid). The experimental protocols involving the use of animals have been subjected to local regulations (RD53/2013 and ECC/566/2015) and the corresponding Regulatory Agencies (<i>Instituto de Salud Carlos III</i>, Complutense University and Community of Madrid). All the procedures included in this report were approved by the Ethic Committees at <i>Instituto de Salud Carlos III</i>, Complutense University and Community of Madrid. All the authors involved in animal experimentation hold the corresponding accreditation (category C, D) granted by the Competent Authority: CAP-T-0771-15, CAM Animal Welfare Committee on Animal Experimentation. Regarding the protection of patients enrolled in the study, we have strictly followed the guidance of Hospital <i>12 de Octubre</i>, the local regulation as well as the “Declaration of Helsinki” and the Guidelines of <i>Good Clinical Practice</i> from the “International Conference on Harmonization” ICH E6 (R2). The protocols for sample collection and processing and any additional material delivered to the patients (i.e., Patient Information Sheets and the Informed Consent Document) were approved by the corresponding Clinical Research Ethic Committee of the Hospital <i>12 de Octubre</i> (CEIm 21/072), in accordance with national legislation.

: The authors declare no competing financial interests.