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Exercise effects on lean body mass, muscle strength and functional performance in patients with metastatic breast cancer: the randomized controlled PREFERABLE-EFFECT study

Crossref DOI link: https://doi.org/10.1186/s13058-026-02235-6

Published Online: 2026-04-13

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zopf, Eva M. https://orcid.org/0000-0001-6250-0041
Joernaker, Gustav

Clauss, Dorothea

Trevaskis, Mark

Hiensch, Anouk E.

Schmidt, Martina E.

Monninkhof, Evelyn M.

Zimmer, Philipp

Belloso, Jon

Heyrman, Elisa

Fernandez Gonzalo, Rodrigo

Wiskemann, Joachim

Müller, Jana

Bolam, Kate A.

Gorecki, Maciej

Altena, Renske

Muttiah, Christine

van der Wall, Elsken

Aaronson, Neil K.

Senkus, Elzbieta

Urruticoechea, Ander

Stuiver, Martijn M.

Steindorf, Karen

Bloch, Wilhelm

Wengström, Yvonne

May, Anne M.

Rundqvist, Helene
Funding

Funding for this research was provided by:

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))

European Union’s Horizon 2020 research and innovation program and the National Health and Medical Research Council of Australia ((No 825677) and (2018/GNT1170698))
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Text and Data Mining valid from 2026-04-13

Version of Record valid from 2026-05-20
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Article History

Received: 3 November 2025

Accepted: 2 February 2026

First Online: 13 April 2026

Declarations

:

: The study was conducted in accordance with the standards of Good Clinical Practice and the Declaration of Helsinki. The conduct of the study was approved by the local ethical review boards of all participating institutions. Informed consent was obtained from all individual participants included in the study.

: The manuscript contains no individual person’s data in any form.

: AMM’s institution, UMC Utrecht, have received fees from Eli Lilly and Company for the development of an e-learning tool on exercise and cancer. All other authors declare that they have no competing interests.

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