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Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds

Crossref DOI link: https://doi.org/10.1186/s13059-019-1620-8

Published Online: 2019-02-05

Published Print: 2019-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Teng, Fei

Li, Jing

Cui, Tongtong

Xu, Kai

Guo, Lu

Gao, Qingqin

Feng, Guihai

Chen, Chuanyuan

Han, Dali

Zhou, Qi

Li, Wei
Funding

Funding for this research was provided by:

the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16030400)

National Natural Science Foundation of China (31621004, 31422038)

National Key Research and Development Program (2017YFA0103803)

National Basic Research Program of China (2014CB964800)

CAS Key Projects (QYZDY-SSW-SMC022, QYZDB-SSW-SMC002)
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Article History

Received: 2 July 2018

Accepted: 3 January 2019

First Online: 5 February 2019

Ethics approval and consent to participate

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: Not applicable.

: A patent application has been filed relating to this work. The authors declare that they have no competing interests, and they plan to deposit the reagents in Addgene to freely share with the academic community.

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