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Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs

Crossref DOI link: https://doi.org/10.1186/s13059-020-02059-3

Published Online: 2020-06-29

Published Print: 2020-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Do, Catherine

Dumont, Emmanuel L. P.

Salas, Martha

Castano, Angelica

Mujahed, Huthayfa

Maldonado, Leonel

Singh, Arunjot

DaSilva-Arnold, Sonia C.

Bhagat, Govind

Lehman, Soren

Christiano, Angela M.

Madhavan, Subha

Nagy, Peter L.

Green, Peter H. R.

Feinman, Rena

Trimble, Cornelia

Illsley, Nicholas P.

Marder, Karen

Honig, Lawrence

Monk, Catherine

Goy, Andre

Chow, Kar

Goldlust, Samuel

Kaptain, George

Siegel, David

Tycko, Benjamin https://orcid.org/0000-0001-7811-5164
Funding

Funding for this research was provided by:

National Institutes of Health (R01 MH092580, R21 AI133140, U01 NS100600, P30 CA051008, DP3 DK094400, P50 CA098252)
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Article History

Received: 16 September 2019

Accepted: 27 May 2020

First Online: 29 June 2020

Ethics approval and consent to participate

: Peripheral blood samples were obtained with informed consent under Columbia University I.R.B.-approved protocols AAAI0706 and 7302R. Primary tumor samples were collected by the John Theurer Cancer Center Tissue Biorepository and transferred to the laboratory with final pathological diagnoses in a de-identified manner under Hackensack University Medical Center I.R.B.-approved protocols Pro2108-0589 and Pro2018-0020. All experimental methods comply with the Helsinki Declaration.

: The authors have no competing interests.

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