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Article History

Received: 2 May 2019

Accepted: 15 January 2020

First Online: 10 February 2020

Ethics approval and consent to participate

: <i>Statement on human data</i>: All human samples (de-identified) were handled in accordance with Institutional Review Board (IRB) protocols to SV (2015P000998/MGH), approved by the Partners Human Research Committee Institutional Review Board/MGH IRB. Samples were obtained by David A. Sweetser, and Tim Graubert and Jennifer Lombardi-Story of the Hematologic Malignancies tissue bank oversight committee (protocol DF/HCC 13-583), approved by DF/HCC Office for Human Research Studies, and include written consent for publication and use of patient samples from all patients. All experimental methods used comply with the Helsinki Declaration.<i>Statement on animal data</i>: nod-scid-gamma (NSG), C57Black/6 mice, 10–12 weeks, are obtained from MGH Cox-7 Gnotobiotic animal facility of the AAALAC-accredited Center for Comparative Medicine and Services at MGH. These facilities are supervised by veterinarians in the Center for Comparative Medicine and the MGH Subcommittee for Animal Research (SRAC) and maintained according to the protocol approved by SRAC, and provide services for breeding, regular health checks, histopathology, and macropathology.

: All samples are de-identified, described under the above IRB protocols. The protocols include written consent for publication and use of patient samples from all patients. All experimental methods used comply with the Helsinki Declaration.

: The authors declare that they have no competing interests.