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Article History

Received: 27 September 2021

Accepted: 23 March 2022

First Online: 31 March 2022

Declarations

:

: The human iPSC samples, which were differentiated into the NPCs, were ethically approved by the responsible committee on human experimentation (20-122, Ethikkommission LMU München) as previously published [CitationRef removed].Bone marrow (BM) and peripheral blood (PB) samples from AML patients were obtained from the Department of Internal Medicine III, Ludwig-Maximilians-Universität, Munich, Germany. Specimens were collected for diagnostic purposes. Written informed consent was obtained from the patients. The study was performed in accordance with the ethical standards of the responsible committee on human experimentation (written approval by the Research Ethics Boards of the medical faculty of Ludwig-Maximilians-Universität, Munich, number 068-08 and 222-10) and with the Helsinki Declaration of 1975, as revised in 2013. All animal trials were performed in accordance with the current ethical standards of the official committee on animal experimentation (written approval by Regierung von Oberbayern, ExternalRef removed; ROB-55.2Vet-2532.Vet_02-16-7 and ROB-55.2Vet-2532.Vet_03-16-56).The mouse brain tissues were collected from mice that were bred and housed at the Biology Faculty Animal Facility at Ludwig Maximilian University in accordance with institutional ethical standards. The animal tissue was harvested according to the German Animal Welfare Act Paragraph 4 (organ removal for scientific reasons).

: Not applicable.

: The authors declare that they have no competing interests.