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Salomaa, Veikko
Hveem, Kristian
Åsvold, Bjørn Olav
Kubo, Michiaki
Kamatani, Yoichiro
Okada, Yukinori
Murakami, Yoshinori
Kim, Bong-Jo
Thorsteinsdottir, Unnur
Stefansson, Kari
Zhang, Jifeng
Chen, YEugene
Ho, Yuk-Lam
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Tsao, Philip S.
Chang, Kyong-Mi
Cho, Kelly
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Gaziano, John M.
Wilson, Peter W. F.
Frayling, Timothy M.
Hirschhorn, Joel N.
Kathiresan, Sekar
Mohlke, Karen L.
Sun, Yan V.
Morris, Andrew P.
Boehnke, Michael
Brown, Christopher D.
Natarajan, Pradeep
Deloukas, Panos
Willer, Cristen J.
Assimes, Themistocles L.
Peloso, Gina M. http://orcid.org/0000-0002-5355-8636
Funding for this research was provided by:
NIH/NHLBI (R01HL127564)
Article History
Received: 5 April 2022
Accepted: 6 December 2022
First Online: 27 December 2022
Declarations
:
: The overall study was approved by the IRB of the Boston University Medical Center. Individual studies were approved by the appropriate institutional review boards (IRB) and informed consent was obtained from all participants.
: Ioanna Ntalla is an employee and stock owner of Gilead Sciences since August 2019. Derek Klarin accepts consulting fees from Regeneron Pharmaceuticals. All deCODE-affiliated authors (Gudmar Thorleifsson, Anna Helgadottir, Daniel F Gudbjartsson, Hilma Holm, Unnur Thorsteinsdottir, Kari Stefansson) are employees of deCODE/Amgen Inc. As of January 2020, Anubha Mahajan is an employee of Genentech, and a holder of Roche stock. Markus Scholz receives funding from Pfizer Inc. for a project not related to this research. Marcus E Kleber is employed by SYNLAB MVZ Mannheim GmbH. Gabriel Cuellar-Partida contributed to this work while employed at The University of Queensland, but he is now an employee of 23andMe Inc. Mark J Caulfield is Chief Scientist for Genomics England, a UK Government company. The views expressed in this article are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. Mark I McCarthy has served on advisory panels for Pfizer, NovoNordisk, and Zoe Global and has received honoraria from Merck, Pfizer, Novo Nordisk, and Eli Lilly and research funding from Abbvie, Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, NovoNordisk, Pfizer, Roche, Sanofi Aventis, Servier, and Takeda. As of June 2019, Mark I McCarthy is an employee of Genentech, and a holder of Roche stock. Winfried März has received grants from Siemens Healthineers, grants and personal fees from Aegerion Pharmaceuticals, grants and personal fees from AMGEN, grants from Astrazeneca, grants and personal fees from Sanofi, grants and personal fees from Alexion Pharmaceuticals, grants and personal fees from BASF, grants and personal fees from Abbott Diagnostics, grants and personal fees from Numares AG, grants and personal fees from Berlin-Chemie, grants and personal fees from Akzea Therapeutics, grants from Bayer Vital GmbH, grants from bestbion dx GmbH, grants from Boehringer Ingelheim Pharma GmbH Co KG, grants from Immundiagnostik GmbH, grants from Merck Chemicals GmbH, grants from MSD Sharp and Dohme GmbH, grants from Novartis Pharma GmbH, grants from Olink Proteomics, other from Synlab Holding Deutschland GmbH, all outside the submitted work. Bruce M Psaty serves on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson. Amit V Khera has served as a consultant to Sanofi, Medicines Company, Maze Pharmaceuticals, Navitor Pharmaceuticals, Verve Therapeutics, Amgen, and Color Genomics; received speaking fees from Illumina, the Novartis Institute for Biomedical Research; received sponsored research agreements from the Novartis Institute for Biomedical Research and IBM Research, and reports a patent related to a genetic risk predictor (20190017119). Dennis O Mook-Kanamori is a part-time clinical research consultant for Metabolon, Inc. Danish Saleheen has received support from the British Heart Foundation, Pfizer, Regeneron, Genentech, and Eli Lilly pharmaceuticals. Veikko Salomaa has received honoraria for consultations from Novo Nordisk and Sanofi and has ongoing research collaboration with Bayer Ltd, all unrelated to the present study. Sekar Kathiresan is an employee of Verve Therapeutics, and holds equity in Verve Therapeutics, Maze Therapeutics, Catabasis, and San Therapeutics. He is a member of the scientific advisory boards for Regeneron Genetics Center and Corvidia Therapeutics; he has served as a consultant for Acceleron, Eli Lilly, Novartis, Merck, Novo Nordisk, Novo Ventures, Ionis, Alnylam, Aegerion, Haug Partners, Noble Insights, Leerink Partners, Bayer Healthcare, Illumina, Color Genomics, MedGenome, Quest, and Medscape; he reports patents related to a method of identifying and treating a person having a predisposition to or afflicted with cardiometabolic disease (20180010185) and a genetics risk predictor (20190017119). Cristen J Willer’s spouse is employed by Regeneron.