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Authors
Trang, Khanh B.
Sharma, Prabhat
Cook, Laura
Mount, Zachary
Thomas, Rajan M.
Kulkarni, Nikhil N.
Cabrera, Emylette Cruz
Rachimi, Suzanna
Pahl, Matthew C.
Pippin, James A.
Su, Chun
Kaestner, Klaus H.
O’Brien, Joan M.
Wagley, Yadav
Hankenson, Kurt D.
Jermusyk, Ashley
Hoskins, Jason W.
Amundadottir, Laufey T.
Xu, Mai
Brown, Kevin M.
Anderson, Stewart A.
Yang, Wenli
Titchenell, Paul M.
Seale, Patrick
Zemel, Babette S.
Chesi, Alessandra
Romberg, Neil
Levings, Megan K.
Grant, Struan F. A.
Wells, Andrew D.
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Funding
Funding for this research was provided by:
BC Children’s Hospital Foundation Bertram Hoffmeister Postdoctoral Fellowship
National Institute of Allergy and Infectious Diseases (R01 AI146026)
Canadian Institutes of Health Research (FDN-154304)
award from the BC Children's Hospital Research Institute and Canada Research Chair in Engineered Immune Tolerance
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK122586)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD056465)
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Article History
Received: 11 June 2025
Accepted: 19 November 2025
First Online: 8 December 2025
Declarations
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: This study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was reviewed and approved by the University of Pennsylvania Institutional Review Board (Protocol #705906). Written informed consent for participation and publication was obtained from all participants (or their legal guardians).For T cell subsets, peripheral blood in the form of buffy coat products was obtained from anonymized healthy adults via Canadian Blood Services (Vancouver BC, Canada) with informed consent and ethical approval from The University of British Columbia Clinical and Canadian Blood Service Research Ethics Boards (H18-02553).
: All authors consent to this work being published at Genome Biology.
: The authors declare no competing interests.
