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Authors
Simmons, Sean K. https://orcid.org/0000-0002-1537-4000
Adiconis, Xian https://orcid.org/0000-0002-4052-2503
Haywood, Nathan https://orcid.org/0000-0003-2213-5080
Parker, Jacob https://orcid.org/0000-0001-9425-6418
Lin, Zechuan https://orcid.org/0000-0003-2270-5194
Liao, Zhixiang https://orcid.org/0000-0001-7014-5465
Tuncali, Idil https://orcid.org/0000-0001-7437-285X
Shin, Asa https://orcid.org/0009-0003-1362-6635
Jagadeesh, Karthik https://orcid.org/0000-0002-0957-812X
Gosik, Kirk https://orcid.org/0000-0001-7612-2176
Gatzen, Michael https://orcid.org/0000-0001-5390-0705
Smith, Jonathan T. https://orcid.org/0000-0002-4279-8220
El Kodsi, Daniel N. https://orcid.org/0000-0002-8896-0043
Kuras, Yuliya https://orcid.org/0000-0001-5388-3669
Baecher-Allan, Clare https://orcid.org/0000-0003-2405-8525
Serrano, Geidy E. https://orcid.org/0000-0002-9527-2011
Beach, Thomas G. https://orcid.org/0000-0003-3296-6128
Garimella, Kiran https://orcid.org/0000-0002-6212-5736
Al’Khafaji, Aziz M. https://orcid.org/0000-0002-4677-5667
Rozenblatt-Rosen, Orit https://orcid.org/0000-0001-6313-3570
Regev, Aviv https://orcid.org/0000-0003-3293-3158
Dong, Xianjun https://orcid.org/0000-0002-8052-9320
Scherzer, Clemens R. https://orcid.org/0000-0002-0567-9193
Levin, Joshua Z. https://orcid.org/0000-0002-0170-3598
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Funding
Funding for this research was provided by:
Aligning Science Across Parkinson's
Klarman Cell Observatory, Broad Institute
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Article History
Received: 13 August 2024
Accepted: 25 March 2026
First Online: 11 April 2026
Declarations
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: Ethics approval and consent information for GTEx samples have been previously published [ ]. For PD-related samples, brain autopsies were approved by the local IRB of the Banner Brain and Body Donation program (IRB # 20120821). The PD-related studies described here were approved by the Institutional Review Boards of Mass General Brigham (IRB # 2006P001261) and Yale (IRB # 2000037299). Experimental methods comply with the Helsinki Declaration.
: Not applicable.
: A.M.A., K.G., and J.T.S. are inventors on a licensed, pending international patent application, having serial number PCT/US2021/037226, filed by Broad Institute of MIT and Havard, Massachusetts General Hospital and Massachusetts Institute of Technology, directed to certain subject matter related to the MAS-seq/Kinnex method described in this manuscript. From October 19, 2020, O.R.R. is an employee of Genentech and has equity in Roche. O.R.R. is a co-inventor on patent applications filed by the Broad Institute for inventions related to single-cell genomics. She has given numerous lectures on the subject of single-cell genomics to a wide variety of audiences and, in some cases, has received remuneration to cover time and costs. A.R. is a cofounder of and equity holder in Celsius Therapeutics, an equity holder in Immunitas and was a Scientific Advisory Board member of Thermo Fisher Scientific, Syros Pharmaceuticals, Neogene Therapeutics and Asimov until 31 July 2020. A.R. has been an employee of Genentech (member of the Roche Group) since August 2020 and has equity in Roche. The other authors declare that they have no competing interests.
