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Authors
Verma, Manasvi https://orcid.org/0000-0002-8348-2556
Adamthwaite, Madison L. https://orcid.org/0000-0002-5468-0916
Desai, Kushaal https://orcid.org/0009-0008-1452-3407
Ding, Yufang https://orcid.org/0000-0001-6633-8192
Wang, Xingren https://orcid.org/0009-0001-8764-0611
Bae, Minwoo https://orcid.org/0000-0002-0313-5520
Rakoff-Nahoum, Seth https://orcid.org/0000-0002-3233-0675
Balskus, Emily P. https://orcid.org/0000-0001-5985-5714
Fischbach, Michael A. https://orcid.org/0000-0003-3079-8247
Jost, Marco https://orcid.org/0000-0002-1369-4908
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Funding
Funding for this research was provided by:
EPSRC Centre for Doctoral Training in BioDesign Engineering (EP/S022856/1)
National Institutes of Health (K08AI130392-01)
National Institutes of Health (R00GM130964)
Burroughs Wellcome Fund Career Award for Medical Scientists
Pew Charitable Trusts (Biomedical Scholarship)
Food Allergy Science Initiative
Howard Hughes Medical Institute
Charles H. Hood Foundation
G. Harold and Leila Y. Mathers Foundation
William F. Milton Fund at Harvard University
Springer-Nature Global Grant for Gut Health (1772808)
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Article History
Received: 15 September 2025
Accepted: 28 September 2026
First Online: 9 October 2026
Declarations
Ethics approval and consent to participate: Not applicable.
Consent for publication: Not applicable.
Competing interests: MJ consults for DEM BioPharma. The Regents of the University of California with MJ as an inventor have filed patent applications related to CRISPRi/a screening. These applications do not imply limitations to reproduce the results in this study or to use the methods described. MAF is a cofounder of Kelonia and Revolution Medicines, a co-founder and director of Azalea, a member of the scientific advisory boards of the Chan Zuckerberg Initiative and TCG Laboratories/Soleil Laboratories, a bio advisor to Amplify Partners, and a science partner at The Column Group. SRN is a founder of Belcanto Bio, Inc. All other co-authors declare no competing interests.
