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Gliadin-dependent UPR induction directly triggers the expression of TG2 and pro-inflammatory cytokines, dysregulates intestinal permeability, and reduces CFTR expression in intestinal epithelial cells of celiac disease patients

Crossref DOI link: https://doi.org/10.1186/s13062-025-00644-9

Published Online: 2025-04-17

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Monzani, Romina

Gagliardi, Mara

Saverio, Valentina

Clemente, Nausicaa

Monzani, Alice

Rabbone, Ivana

Nigrelli, Francesca

Pellizzaro, Samuele

Ferrario, Emanuele

Saettone, Silvia

Pagano, Nico

De Leo, Luigina

Lim, Dmitry

Sblattero, Daniele

Corazzari, Marco
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Article History

Received: 21 February 2025

Accepted: 28 March 2025

First Online: 17 April 2025

Declarations

:

: All procedures were approved by the local Ethics Committee for Animal Welfare (DB064.N.TMC) and conformed to the European Community regulations for animal use in research (2010/63 UE). Parents or guardians and patients, where appropriate, provided written informed consent, and the local ethics committee (Comitato Etico Interaziendale Novara, CE 402/23) approved the study protocol.

: The authors declare no conflict of interests.

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