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Article History

Received: 27 November 2017

Accepted: 1 February 2018

First Online: 5 March 2018

Ethics approval and consent to participate

: The protocol was written according to general ethical guidelines of the Declaration of Helsinki and Korean Good Clinical Practice. The protocol was also approved by the Institutional Review Board of each trial center (protocol number 2017–0002, protocol version 3.1) and was registered at ClinicalTrials.gov. All participants will be informed of the methods of the trial, including potential benefits, possible adverse events, and personal responsibilities, and will then provide written informed consent.

: All authors have reviewed the final manuscript, and consent for publication. There are no personal or private data contained in this manuscript.

: The authors declare that they have no competing interests.

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