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Article History

Received: 8 May 2018

Accepted: 1 November 2018

First Online: 29 November 2018

Ethics approval and consent to participate

: This study was approved by the Medicine Scientific Ethics Committee (Comité Científico Ético de Medicina) of the Pontificia Universidad Católica de Chile, Santiago, Chile (CÓDIGO 15–221). This committee will be in charge of conducting an audit of the ethical aspects of the trial before its termination. Any protocol modification will be sent to the committee for approval and once it is approved it will be notified to the trial registration agencies. All eligible participants who will be willing to participate will go through an informed consent process, conducted by a research assistant who is not a member of the patient’s medical team. This research will be carried out in accordance with the Declaration of Helsinki.

: Consent for publication will be obtained from each participant prior to participation.

: The authors declare that they have no competing interests.

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